Combined Fourier-transform infrared imaging and desorption electrospray-ionization linear ion-trap mass spectrometry for analysis of counterfeit antimalarial tablets
This paper reports use of a combination of Fourier-transform infrared (FTIR) spectroscopic imaging and desorption electrospray ionization linear ion-trap mass spectrometry (DESI MS) for characterization of counterfeit pharmaceutical tablets. The counterfeit artesunate antimalarial tablets were analy...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2007-01, Vol.387 (2), p.551-559 |
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| container_title | Analytical and bioanalytical chemistry |
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| creator | Ricci, Camilla Nyadong, Leonard Fernandez, Facundo M Newton, Paul N Kazarian, Sergei G |
| description | This paper reports use of a combination of Fourier-transform infrared (FTIR) spectroscopic imaging and desorption electrospray ionization linear ion-trap mass spectrometry (DESI MS) for characterization of counterfeit pharmaceutical tablets. The counterfeit artesunate antimalarial tablets were analyzed by both techniques. The results obtained revealed the ability of FTIR imaging in non-destructive micro-attenuated total reflection (ATR) mode to detect the distribution of all components in the tablet, the identities of which were confirmed by DESI MS. Chemical images of the tablets were obtained with high spatial resolution. The FTIR spectroscopic imaging method affords inherent chemical specificity with rapid acquisition of data. DESI MS enables high-sensitivity detection of trace organic compounds. Combination of these two orthogonal surface-characterization methods has great potential for detection and analysis of counterfeit tablets in the open air and without sample preparation. |
| doi_str_mv | 10.1007/s00216-006-0950-z |
| format | Article |
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Combination of these two orthogonal surface-characterization methods has great potential for detection and analysis of counterfeit tablets in the open air and without sample preparation.</description><subject>Antimalarials - analysis</subject><subject>Antimalarials - standards</subject><subject>Artemisinins - analysis</subject><subject>Artesunate</subject><subject>Chemical imaging</subject><subject>Diagnostic Imaging</subject><subject>Drug Contamination</subject><subject>Fake drugs</subject><subject>Forensic</subject><subject>malaria</subject><subject>mass spectrometry</subject><subject>Quality Control</subject><subject>Sesquiterpenes - analysis</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Spectroscopy, Fourier Transform Infrared - methods</subject><subject>Tablets - analysis</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-OFCEQh4nRuH_0AbwoJ2-tVUDT3UczcV2TTTzongndwARDNy3Qh5n38T1ldiZ69ECoFF99BH6EvEH4gADdxwzAUDYAdQ0tNMdn5Bol9g2TLTz_Wwt2RW5y_gmAbY_yJbnCDrnkAq7J712cR79YQ-_ilrxNTUl6yS6mmfrFJZ3qkZ_13i97qhdDjc0xrcXHhdpgp5JiXpM-NLXhj_qpH6pPJ1rLk2yls86Z5vUJnm1JB1r1VabDIftMo6NT3JZik7O-1H6p9wWdvA606DHYkl-RF06HbF9f9lvyePf5x-6-efj25evu00MzCQalMSCsYVwioJTgmOhG0QnhhpYPljE3cmcMTsBa00nJcWqxNwIH06LkBhi_Je_P3jXFX5vNRc0-TzYEvdi4ZSV7AVJ08F-QDS3jAnkF8QxO9aNysk6tqT4vHRSCOoWoziGqGqI6haiOdebtRb6NszX_Ji6pVeDdGXA6Kr1PPqvH7wyQV1_HejbwPxWspXI</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Ricci, Camilla</creator><creator>Nyadong, Leonard</creator><creator>Fernandez, Facundo M</creator><creator>Newton, Paul N</creator><creator>Kazarian, Sergei G</creator><general>Berlin/Heidelberg : Springer-Verlag</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Combined Fourier-transform infrared imaging and desorption electrospray-ionization linear ion-trap mass spectrometry for analysis of counterfeit antimalarial tablets</title><author>Ricci, Camilla ; 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| ispartof | Analytical and bioanalytical chemistry, 2007-01, Vol.387 (2), p.551-559 |
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| subjects | Antimalarials - analysis Antimalarials - standards Artemisinins - analysis Artesunate Chemical imaging Diagnostic Imaging Drug Contamination Fake drugs Forensic malaria mass spectrometry Quality Control Sesquiterpenes - analysis Spectrometry, Mass, Electrospray Ionization - methods Spectroscopy, Fourier Transform Infrared - methods Tablets - analysis |
| title | Combined Fourier-transform infrared imaging and desorption electrospray-ionization linear ion-trap mass spectrometry for analysis of counterfeit antimalarial tablets |
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