Decreased Serum Levels of Platelet-Endothelial Adhesion Molecule (PECAM-1) in Subjects with High-Functioning Autism: A Negative Correlation with Head Circumference at Birth
Background Accumulating evidence suggests that the immune system plays a role in the pathophysiology of autism, and that the adhesion molecules play an important role in the process of inflammation. This study was undertaken to determine whether serum levels of the adhesion molecules in subjects wit...
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| Veröffentlicht in: | Biological psychiatry (1969) 2007-11, Vol.62 (9), p.1056-1058 |
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| creator | Tsuchiya, Kenji J Hashimoto, Kenji Iwata, Yasuhide Tsujii, Masatsugu Sekine, Yoshimoto Sugihara, Genichi Matsuzaki, Hideo Suda, Shiro Kawai, Masayoshi Nakamura, Kazuhiko Minabe, Yoshio Yagi, Atsuko Iyo, Masaomi Takei, Nori Mori, Norio |
| description | Background Accumulating evidence suggests that the immune system plays a role in the pathophysiology of autism, and that the adhesion molecules play an important role in the process of inflammation. This study was undertaken to determine whether serum levels of the adhesion molecules in subjects with high-functioning autism are altered as compared with those of normal controls. Methods Seventeen male subjects with high-functioning autism and 22 male age-matched unrelated healthy control subjects were enrolled. Serum levels of the soluble forms of platelet-endothelial adhesion molecule (PECAM-1), intracellular adhesion molecule (ICAM-1), and vascular cell adhesion molecule (VCAM-1) were measured. Results Levels of PECAM-1, but not ICAM-1, in the subjects with autism were significantly lower than those of control subjects. VCAM-1 showed a weak trend for a lowered level. There was a negative correlation between serum levels of PECAM-1 and head circumference at birth in the autistic subjects. Conclusions These results suggest that PECAM-1 plays a role in the pathophysiology of high-functioning autism. |
| doi_str_mv | 10.1016/j.biopsych.2006.12.018 |
| format | Article |
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This study was undertaken to determine whether serum levels of the adhesion molecules in subjects with high-functioning autism are altered as compared with those of normal controls. Methods Seventeen male subjects with high-functioning autism and 22 male age-matched unrelated healthy control subjects were enrolled. Serum levels of the soluble forms of platelet-endothelial adhesion molecule (PECAM-1), intracellular adhesion molecule (ICAM-1), and vascular cell adhesion molecule (VCAM-1) were measured. Results Levels of PECAM-1, but not ICAM-1, in the subjects with autism were significantly lower than those of control subjects. VCAM-1 showed a weak trend for a lowered level. There was a negative correlation between serum levels of PECAM-1 and head circumference at birth in the autistic subjects. Conclusions These results suggest that PECAM-1 plays a role in the pathophysiology of high-functioning autism.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2006.12.018</identifier><identifier>PMID: 17509538</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adhesion molecules ; Adolescent ; Adult ; Analysis of Variance ; Autistic Disorder - blood ; Biological and medical sciences ; Cephalometry ; Child clinical studies ; Developmental disorders ; ELISA ; Enzyme-Linked Immunosorbent Assay - methods ; Head - pathology ; head circumference ; high-functioning autism ; human blood ; Humans ; Infantile autism ; Intercellular Adhesion Molecule-1 - metabolism ; Male ; Medical sciences ; Parturition ; Platelet Endothelial Cell Adhesion Molecule-1 - blood ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Severity of Illness Index ; Vascular Cell Adhesion Molecule-1 - blood</subject><ispartof>Biological psychiatry (1969), 2007-11, Vol.62 (9), p.1056-1058</ispartof><rights>Society of Biological Psychiatry</rights><rights>2007 Society of Biological Psychiatry</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-b20471718e302d6c5b690cb82a3b9f085a6a9c61c8c6a5bc380eef3817d561963</citedby><cites>FETCH-LOGICAL-c482t-b20471718e302d6c5b690cb82a3b9f085a6a9c61c8c6a5bc380eef3817d561963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopsych.2006.12.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19211846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17509538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuchiya, Kenji J</creatorcontrib><creatorcontrib>Hashimoto, Kenji</creatorcontrib><creatorcontrib>Iwata, Yasuhide</creatorcontrib><creatorcontrib>Tsujii, Masatsugu</creatorcontrib><creatorcontrib>Sekine, Yoshimoto</creatorcontrib><creatorcontrib>Sugihara, Genichi</creatorcontrib><creatorcontrib>Matsuzaki, Hideo</creatorcontrib><creatorcontrib>Suda, Shiro</creatorcontrib><creatorcontrib>Kawai, Masayoshi</creatorcontrib><creatorcontrib>Nakamura, Kazuhiko</creatorcontrib><creatorcontrib>Minabe, Yoshio</creatorcontrib><creatorcontrib>Yagi, Atsuko</creatorcontrib><creatorcontrib>Iyo, Masaomi</creatorcontrib><creatorcontrib>Takei, Nori</creatorcontrib><creatorcontrib>Mori, Norio</creatorcontrib><title>Decreased Serum Levels of Platelet-Endothelial Adhesion Molecule (PECAM-1) in Subjects with High-Functioning Autism: A Negative Correlation with Head Circumference at Birth</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background Accumulating evidence suggests that the immune system plays a role in the pathophysiology of autism, and that the adhesion molecules play an important role in the process of inflammation. This study was undertaken to determine whether serum levels of the adhesion molecules in subjects with high-functioning autism are altered as compared with those of normal controls. Methods Seventeen male subjects with high-functioning autism and 22 male age-matched unrelated healthy control subjects were enrolled. Serum levels of the soluble forms of platelet-endothelial adhesion molecule (PECAM-1), intracellular adhesion molecule (ICAM-1), and vascular cell adhesion molecule (VCAM-1) were measured. Results Levels of PECAM-1, but not ICAM-1, in the subjects with autism were significantly lower than those of control subjects. VCAM-1 showed a weak trend for a lowered level. There was a negative correlation between serum levels of PECAM-1 and head circumference at birth in the autistic subjects. Conclusions These results suggest that PECAM-1 plays a role in the pathophysiology of high-functioning autism.</description><subject>Adhesion molecules</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Autistic Disorder - blood</subject><subject>Biological and medical sciences</subject><subject>Cephalometry</subject><subject>Child clinical studies</subject><subject>Developmental disorders</subject><subject>ELISA</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Head - pathology</subject><subject>head circumference</subject><subject>high-functioning autism</subject><subject>human blood</subject><subject>Humans</subject><subject>Infantile autism</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parturition</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - blood</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Severity of Illness Index</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksGO0zAQhiMEYsvCK6x8AcEhxXYSx-GAKKXLInVhpcLZcpxJ4-LExXaK-k48JI5atBKXPVmWv3_G9jdJckXwnGDC3u7mtbZ7f1TdnGLM5oTOMeGPkhnhZZbSHNPHyQzHkzSjNLtInnm_i9uSUvI0uSBlgasi47PkzydQDqSHBm3AjT1awwGMR7ZFd0YGMBDS1dDY0IHR0qBF04HXdkC31oAaDaDXd6vl4jYlb5Ae0Gasd6CCR7916NCN3nbp9TioEBN62KLFGLTv36EF-gpbGfQB0NI6B7HTVPMUAtmgpXZq7FtwMChAMqCP2oXuefKklcbDi_N6mfy4Xn1f3qTrb5-_LBfrVOWchrSmOC9JSThkmDZMFTWrsKo5lVldtZgXkslKMaK4YrKoVcYxQJtxUjYFIxXLLpNXp7p7Z3-N4IPotVdgjBzAjl4wnuOiqqoHQYpZyTOeR5CdQOWs9w5asXe6l-4oCBaTULET_4SKSaggVEShMXh17jDWPTT3sbPBCLw8A9IraVonB6X9PVdRQng-venDiYt24aDBCa_09LuNdtGYaKx--C7v_yuhjB507PoTjuB3dnRD1CKI8DEgNtP4TdOHGSYFJzT7C17A15I</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Tsuchiya, Kenji J</creator><creator>Hashimoto, Kenji</creator><creator>Iwata, Yasuhide</creator><creator>Tsujii, Masatsugu</creator><creator>Sekine, Yoshimoto</creator><creator>Sugihara, Genichi</creator><creator>Matsuzaki, Hideo</creator><creator>Suda, Shiro</creator><creator>Kawai, Masayoshi</creator><creator>Nakamura, Kazuhiko</creator><creator>Minabe, Yoshio</creator><creator>Yagi, Atsuko</creator><creator>Iyo, Masaomi</creator><creator>Takei, Nori</creator><creator>Mori, Norio</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Decreased Serum Levels of Platelet-Endothelial Adhesion Molecule (PECAM-1) in Subjects with High-Functioning Autism: A Negative Correlation with Head Circumference at Birth</title><author>Tsuchiya, Kenji J ; Hashimoto, Kenji ; Iwata, Yasuhide ; Tsujii, Masatsugu ; Sekine, Yoshimoto ; Sugihara, Genichi ; Matsuzaki, Hideo ; Suda, Shiro ; Kawai, Masayoshi ; Nakamura, Kazuhiko ; Minabe, Yoshio ; Yagi, Atsuko ; Iyo, Masaomi ; Takei, Nori ; Mori, Norio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-b20471718e302d6c5b690cb82a3b9f085a6a9c61c8c6a5bc380eef3817d561963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adhesion molecules</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Autistic Disorder - blood</topic><topic>Biological and medical sciences</topic><topic>Cephalometry</topic><topic>Child clinical studies</topic><topic>Developmental disorders</topic><topic>ELISA</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Head - pathology</topic><topic>head circumference</topic><topic>high-functioning autism</topic><topic>human blood</topic><topic>Humans</topic><topic>Infantile autism</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parturition</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - blood</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Severity of Illness Index</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuchiya, Kenji J</creatorcontrib><creatorcontrib>Hashimoto, Kenji</creatorcontrib><creatorcontrib>Iwata, Yasuhide</creatorcontrib><creatorcontrib>Tsujii, Masatsugu</creatorcontrib><creatorcontrib>Sekine, Yoshimoto</creatorcontrib><creatorcontrib>Sugihara, Genichi</creatorcontrib><creatorcontrib>Matsuzaki, Hideo</creatorcontrib><creatorcontrib>Suda, Shiro</creatorcontrib><creatorcontrib>Kawai, Masayoshi</creatorcontrib><creatorcontrib>Nakamura, Kazuhiko</creatorcontrib><creatorcontrib>Minabe, Yoshio</creatorcontrib><creatorcontrib>Yagi, Atsuko</creatorcontrib><creatorcontrib>Iyo, Masaomi</creatorcontrib><creatorcontrib>Takei, Nori</creatorcontrib><creatorcontrib>Mori, Norio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuchiya, Kenji J</au><au>Hashimoto, Kenji</au><au>Iwata, Yasuhide</au><au>Tsujii, Masatsugu</au><au>Sekine, Yoshimoto</au><au>Sugihara, Genichi</au><au>Matsuzaki, Hideo</au><au>Suda, Shiro</au><au>Kawai, Masayoshi</au><au>Nakamura, Kazuhiko</au><au>Minabe, Yoshio</au><au>Yagi, Atsuko</au><au>Iyo, Masaomi</au><au>Takei, Nori</au><au>Mori, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Serum Levels of Platelet-Endothelial Adhesion Molecule (PECAM-1) in Subjects with High-Functioning Autism: A Negative Correlation with Head Circumference at Birth</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>62</volume><issue>9</issue><spage>1056</spage><epage>1058</epage><pages>1056-1058</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background Accumulating evidence suggests that the immune system plays a role in the pathophysiology of autism, and that the adhesion molecules play an important role in the process of inflammation. This study was undertaken to determine whether serum levels of the adhesion molecules in subjects with high-functioning autism are altered as compared with those of normal controls. Methods Seventeen male subjects with high-functioning autism and 22 male age-matched unrelated healthy control subjects were enrolled. Serum levels of the soluble forms of platelet-endothelial adhesion molecule (PECAM-1), intracellular adhesion molecule (ICAM-1), and vascular cell adhesion molecule (VCAM-1) were measured. Results Levels of PECAM-1, but not ICAM-1, in the subjects with autism were significantly lower than those of control subjects. VCAM-1 showed a weak trend for a lowered level. There was a negative correlation between serum levels of PECAM-1 and head circumference at birth in the autistic subjects. Conclusions These results suggest that PECAM-1 plays a role in the pathophysiology of high-functioning autism.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17509538</pmid><doi>10.1016/j.biopsych.2006.12.018</doi><tpages>3</tpages></addata></record> |
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| subjects | Adhesion molecules Adolescent Adult Analysis of Variance Autistic Disorder - blood Biological and medical sciences Cephalometry Child clinical studies Developmental disorders ELISA Enzyme-Linked Immunosorbent Assay - methods Head - pathology head circumference high-functioning autism human blood Humans Infantile autism Intercellular Adhesion Molecule-1 - metabolism Male Medical sciences Parturition Platelet Endothelial Cell Adhesion Molecule-1 - blood Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Severity of Illness Index Vascular Cell Adhesion Molecule-1 - blood |
| title | Decreased Serum Levels of Platelet-Endothelial Adhesion Molecule (PECAM-1) in Subjects with High-Functioning Autism: A Negative Correlation with Head Circumference at Birth |
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