Fine specificity of antibodies against phospholipids and beta-2-glycoprotein I in monoclonal gammopathy associated neuropathies
Abstract Phospholipids are abundantly represented within the nervous system. Aim of our study was to evaluate the presence and fine specificity of anti phospholipid antibodies (aPLAb) among patients with monoclonal gammopathy associated neuropathy. Thirty nine percent of these patients had high tite...
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| Veröffentlicht in: | Journal of neuroimmunology 2007-01, Vol.182 (1), p.219-225 |
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| creator | Matà, Sabrina Grazia Giudizi, Maria Totaro, Maria Grippo, Antonello Fedi, Sandra Sorbi, Sandro |
| description | Abstract Phospholipids are abundantly represented within the nervous system. Aim of our study was to evaluate the presence and fine specificity of anti phospholipid antibodies (aPLAb) among patients with monoclonal gammopathy associated neuropathy. Thirty nine percent of these patients had high titers of aPLAb, mostly associated with low levels of anti beta2 glycoprotein I, which suggests different antibody specificity compared to patients with anti phospholipid syndrome. Further 6/48 patients with dysimmune neuropathy without monoclonal gammopathy had positive aPLAb titers. APLAb strongly cross-reacted with sulfatide. These findings suggest an adjuntive role of aPLAb on nerve damage and may help to better understand the nerve binding properties of anti-sulfatide antibodies. |
| doi_str_mv | 10.1016/j.jneuroim.2006.10.016 |
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Aim of our study was to evaluate the presence and fine specificity of anti phospholipid antibodies (aPLAb) among patients with monoclonal gammopathy associated neuropathy. Thirty nine percent of these patients had high titers of aPLAb, mostly associated with low levels of anti beta2 glycoprotein I, which suggests different antibody specificity compared to patients with anti phospholipid syndrome. Further 6/48 patients with dysimmune neuropathy without monoclonal gammopathy had positive aPLAb titers. APLAb strongly cross-reacted with sulfatide. These findings suggest an adjuntive role of aPLAb on nerve damage and may help to better understand the nerve binding properties of anti-sulfatide antibodies.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2006.10.016</identifier><identifier>PMID: 17161469</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Allergy and Immunology ; Anti-phospholipid antibodies ; Anti-sulfatide antibodies ; Antibodies, Antiphospholipid - blood ; Antibodies, Antiphospholipid - immunology ; Antibody Specificity ; Autoantibodies - immunology ; beta 2-Glycoprotein I - immunology ; Cross Reactions ; Dysimmune neuropathy ; Female ; Humans ; Male ; Middle Aged ; Monoclonal gammopathy ; Movement Disorders - etiology ; Movement Disorders - immunology ; Nervous System Diseases - etiology ; Nervous System Diseases - immunology ; Neurology ; Paraproteinemias - complications ; Polyneuropathies - etiology ; Polyneuropathies - immunology ; Prospective Studies ; Sensation Disorders - etiology ; Sensation Disorders - immunology ; Sulfoglycosphingolipids - immunology</subject><ispartof>Journal of neuroimmunology, 2007-01, Vol.182 (1), p.219-225</ispartof><rights>Elsevier B.V.</rights><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-b665522f185fdfeac9a5c8192b987a921213c9e02d2116a765d3cc20825588e93</citedby><cites>FETCH-LOGICAL-c452t-b665522f185fdfeac9a5c8192b987a921213c9e02d2116a765d3cc20825588e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572806004176$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17161469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matà, Sabrina</creatorcontrib><creatorcontrib>Grazia Giudizi, Maria</creatorcontrib><creatorcontrib>Totaro, Maria</creatorcontrib><creatorcontrib>Grippo, Antonello</creatorcontrib><creatorcontrib>Fedi, Sandra</creatorcontrib><creatorcontrib>Sorbi, Sandro</creatorcontrib><title>Fine specificity of antibodies against phospholipids and beta-2-glycoprotein I in monoclonal gammopathy associated neuropathies</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Phospholipids are abundantly represented within the nervous system. Aim of our study was to evaluate the presence and fine specificity of anti phospholipid antibodies (aPLAb) among patients with monoclonal gammopathy associated neuropathy. Thirty nine percent of these patients had high titers of aPLAb, mostly associated with low levels of anti beta2 glycoprotein I, which suggests different antibody specificity compared to patients with anti phospholipid syndrome. Further 6/48 patients with dysimmune neuropathy without monoclonal gammopathy had positive aPLAb titers. APLAb strongly cross-reacted with sulfatide. These findings suggest an adjuntive role of aPLAb on nerve damage and may help to better understand the nerve binding properties of anti-sulfatide antibodies.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allergy and Immunology</subject><subject>Anti-phospholipid antibodies</subject><subject>Anti-sulfatide antibodies</subject><subject>Antibodies, Antiphospholipid - blood</subject><subject>Antibodies, Antiphospholipid - immunology</subject><subject>Antibody Specificity</subject><subject>Autoantibodies - immunology</subject><subject>beta 2-Glycoprotein I - immunology</subject><subject>Cross Reactions</subject><subject>Dysimmune neuropathy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monoclonal gammopathy</subject><subject>Movement Disorders - etiology</subject><subject>Movement Disorders - immunology</subject><subject>Nervous System Diseases - etiology</subject><subject>Nervous System Diseases - immunology</subject><subject>Neurology</subject><subject>Paraproteinemias - complications</subject><subject>Polyneuropathies - etiology</subject><subject>Polyneuropathies - immunology</subject><subject>Prospective Studies</subject><subject>Sensation Disorders - etiology</subject><subject>Sensation Disorders - immunology</subject><subject>Sulfoglycosphingolipids - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFv1DAQhS0EotvCX6h84pat7cSOc0GgikKlShyAs-XYk-0siR3iBCkn_joOuwiJSw-2pU9v5o38hpBrzvaccXVz3B8DLFPEYS8YUxnuM35GdlzXotCV4M_JLhNZyFroC3KZ0pExLsuqeUkueM0Vr1SzI7_uMABNIzjs0OG80thRG2Zso0dI1B4shjTT8TGmfHoc0WcaPG1htoUoDv3q4jjFGTDQe5qvIYbo-hhsTw92GOJo58eV2pSiQzuDp38G32g2eEVedLZP8Pr8XpFvdx--3n4qHj5_vL99_1C4Soq5aJWSUoiOa9n5DqxrrHSaN6JtdG0bwQUvXQNMeMG5srWSvnROMC2k1Bqa8oq8OfXNo_5YIM1mwOSg722AuCSjdMWkEuxJoWCi1kzLLFQnoZtiShN0ZpxwsNNqODNbRuZo_mZktow2nnEuvD47LO0A_l_ZOZQseHcSQP6QnwiTSQ4hOPA4gZuNj_i0x9v_WrgeAzrbf4cV0jEuU84nGW6SMMx82TZlWxSmGKt4rcrftU69Yg</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Matà, Sabrina</creator><creator>Grazia Giudizi, Maria</creator><creator>Totaro, Maria</creator><creator>Grippo, Antonello</creator><creator>Fedi, Sandra</creator><creator>Sorbi, Sandro</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Fine specificity of antibodies against phospholipids and beta-2-glycoprotein I in monoclonal gammopathy associated neuropathies</title><author>Matà, Sabrina ; Grazia Giudizi, Maria ; Totaro, Maria ; Grippo, Antonello ; Fedi, Sandra ; Sorbi, Sandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-b665522f185fdfeac9a5c8192b987a921213c9e02d2116a765d3cc20825588e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allergy and Immunology</topic><topic>Anti-phospholipid antibodies</topic><topic>Anti-sulfatide antibodies</topic><topic>Antibodies, Antiphospholipid - blood</topic><topic>Antibodies, Antiphospholipid - immunology</topic><topic>Antibody Specificity</topic><topic>Autoantibodies - immunology</topic><topic>beta 2-Glycoprotein I - immunology</topic><topic>Cross Reactions</topic><topic>Dysimmune neuropathy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monoclonal gammopathy</topic><topic>Movement Disorders - etiology</topic><topic>Movement Disorders - immunology</topic><topic>Nervous System Diseases - etiology</topic><topic>Nervous System Diseases - immunology</topic><topic>Neurology</topic><topic>Paraproteinemias - complications</topic><topic>Polyneuropathies - etiology</topic><topic>Polyneuropathies - immunology</topic><topic>Prospective Studies</topic><topic>Sensation Disorders - etiology</topic><topic>Sensation Disorders - immunology</topic><topic>Sulfoglycosphingolipids - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matà, Sabrina</creatorcontrib><creatorcontrib>Grazia Giudizi, Maria</creatorcontrib><creatorcontrib>Totaro, Maria</creatorcontrib><creatorcontrib>Grippo, Antonello</creatorcontrib><creatorcontrib>Fedi, Sandra</creatorcontrib><creatorcontrib>Sorbi, Sandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matà, Sabrina</au><au>Grazia Giudizi, Maria</au><au>Totaro, Maria</au><au>Grippo, Antonello</au><au>Fedi, Sandra</au><au>Sorbi, Sandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fine specificity of antibodies against phospholipids and beta-2-glycoprotein I in monoclonal gammopathy associated neuropathies</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>182</volume><issue>1</issue><spage>219</spage><epage>225</epage><pages>219-225</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Phospholipids are abundantly represented within the nervous system. Aim of our study was to evaluate the presence and fine specificity of anti phospholipid antibodies (aPLAb) among patients with monoclonal gammopathy associated neuropathy. Thirty nine percent of these patients had high titers of aPLAb, mostly associated with low levels of anti beta2 glycoprotein I, which suggests different antibody specificity compared to patients with anti phospholipid syndrome. Further 6/48 patients with dysimmune neuropathy without monoclonal gammopathy had positive aPLAb titers. APLAb strongly cross-reacted with sulfatide. These findings suggest an adjuntive role of aPLAb on nerve damage and may help to better understand the nerve binding properties of anti-sulfatide antibodies.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17161469</pmid><doi>10.1016/j.jneuroim.2006.10.016</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Allergy and Immunology Anti-phospholipid antibodies Anti-sulfatide antibodies Antibodies, Antiphospholipid - blood Antibodies, Antiphospholipid - immunology Antibody Specificity Autoantibodies - immunology beta 2-Glycoprotein I - immunology Cross Reactions Dysimmune neuropathy Female Humans Male Middle Aged Monoclonal gammopathy Movement Disorders - etiology Movement Disorders - immunology Nervous System Diseases - etiology Nervous System Diseases - immunology Neurology Paraproteinemias - complications Polyneuropathies - etiology Polyneuropathies - immunology Prospective Studies Sensation Disorders - etiology Sensation Disorders - immunology Sulfoglycosphingolipids - immunology |
| title | Fine specificity of antibodies against phospholipids and beta-2-glycoprotein I in monoclonal gammopathy associated neuropathies |
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