Implementing a decision-theoretic design in clinical trials: Why and how?

This paper addresses two main questions: first, why should Bayesian and other innovative, data‐dependent design models be put into practice and, secondly, given the past dearth of actual applications, how might one example of such a design be implemented in a genuine example trial? Clinical trials amalgamate theory, practice and ethics, but this last point has become relegated to the background, rather than taking often a more appropriate primary role. Trial practice has evolved but has its roots in R. A. Fisher's randomized agricultural field trials of the 1920s. Reasons for, and consequences of, this are discussed from an ethical standpoint, drawing on an under‐used dichotomy introduced by French authors Lellouch and Schwartz (Int. Statist. Rev. 1971; 39:27–36). Plenty of ethically motivated designs for trials, including Bayesian designs have been proposed, but have found little application thus far. One reason for this is a lack of awareness of such alternative designs among trialists, while another reason is a lack of user‐friendly software to allow study simulations. To encourage implementation, a new C++ program called ‘Daniel’ is introduced, offering much potential to assist the design of today's randomized controlled trials. Daniel evaluates a particular decision‐theoretic method suitable for coping with either two or three Bernoulli response treatments with input features allowing user‐specified choices of: patient horizon (number to be treated before and after the comparative stages of the trial); an arbitrary fixed trial truncation size (to allow ready comparison with traditional designs or to cope with practical constraints); anticipated success rates and a measure of their uncertainty (a matter ignored in standard power calculations); and clinically relevant, and irrelevant, differences in treatment effect sizes. Error probabilities and expected trial durations can be thoroughly explored via simulation, it being better by far to harm ‘computer patients’ instead of real ones. Suppose the objective in a clinical trial is to select between two treatments using a maximum horizon of 500 patients, when the truly superior treatment is expected to yield a 40 per cent success rate, but is believed to really range between 20 and 60 per cent. Simulation studies show that to detect a clinically relevant, absolute difference of 10 per cent between treatments, simulation studies show the decision‐theoretic procedure would treat a mean 68 pairs of patients (