Serotonin Induces a Biphasic Response in Rabbit Cavernosal Smooth Muscle: Relevance to the Erectile Process

Introduction: Serotonin (5-hydroxytryptamine; 5-HT) can cause contraction in cavernosal smooth muscle. We further evaluated this effect of 5-HT. Methods: Organ bath studies were used. Results: 5-HT induced a sustained contraction occasionally accompanied by a transient relaxation (in 30% of rabbit c...

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Veröffentlicht in:	Urologia internationalis 2007-01, Vol.79 (3), p.255-261
Hauptverfasser:	Lau, David H.W., Thompson, Cecil S., Mumtaz, Faiz H., Morgan, Robert J., Mikhailidis, Dimitri P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - pharmacology Animals Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology In Vitro Techniques Male Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - enzymology Muscle, Smooth - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Original Paper Penile Erection - drug effects Penis - drug effects Penis - enzymology Penis - metabolism Rabbits Receptor, Serotonin, 5-HT2A - metabolism Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - metabolism Receptors, Serotonin, 5-HT3 - metabolism Serotonin - metabolism Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT3 Receptor Antagonists Serotonin Antagonists - pharmacology
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