Serotonin Induces a Biphasic Response in Rabbit Cavernosal Smooth Muscle: Relevance to the Erectile Process
Introduction: Serotonin (5-hydroxytryptamine; 5-HT) can cause contraction in cavernosal smooth muscle. We further evaluated this effect of 5-HT. Methods: Organ bath studies were used. Results: 5-HT induced a sustained contraction occasionally accompanied by a transient relaxation (in 30% of rabbit c...
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| Veröffentlicht in: | Urologia internationalis 2007-01, Vol.79 (3), p.255-261 |
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| creator | Lau, David H.W. Thompson, Cecil S. Mumtaz, Faiz H. Morgan, Robert J. Mikhailidis, Dimitri P. |
| description | Introduction: Serotonin (5-hydroxytryptamine; 5-HT) can cause contraction in cavernosal smooth muscle. We further evaluated this effect of 5-HT. Methods: Organ bath studies were used. Results: 5-HT induced a sustained contraction occasionally accompanied by a transient relaxation (in 30% of rabbit cavernosal tissues) that preceded the contraction. Ondansetron and Y-25130 (both 5-HT 3 receptor antagonists) but not SB-269970 (a 5-HT 7 receptor antagonist) significantly inhibited or abolished this transient relaxation. Doxazosin (dox, an α 1 -receptor antagonist) and ketanserin (ketan, a 5-HT 2A receptor antagonist) significantly inhibited or abolished the sustained contraction. The effects of dox on 5-HT-mediated contraction were concentration-dependent. Conclusions: Our findings further confirm that the peripheral serotonergic pathway may play a part in the erectile process via 5-HT 2A receptor-mediated contractile and 5-HT 3 receptor-mediated relaxant activities. Our results also support the findings of human studies, which suggest that both ketan and dox may exert beneficial effects on the erectile process. |
| doi_str_mv | 10.1159/000107959 |
| format | Article |
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We further evaluated this effect of 5-HT. Methods: Organ bath studies were used. Results: 5-HT induced a sustained contraction occasionally accompanied by a transient relaxation (in 30% of rabbit cavernosal tissues) that preceded the contraction. Ondansetron and Y-25130 (both 5-HT 3 receptor antagonists) but not SB-269970 (a 5-HT 7 receptor antagonist) significantly inhibited or abolished this transient relaxation. Doxazosin (dox, an α 1 -receptor antagonist) and ketanserin (ketan, a 5-HT 2A receptor antagonist) significantly inhibited or abolished the sustained contraction. The effects of dox on 5-HT-mediated contraction were concentration-dependent. Conclusions: Our findings further confirm that the peripheral serotonergic pathway may play a part in the erectile process via 5-HT 2A receptor-mediated contractile and 5-HT 3 receptor-mediated relaxant activities. Our results also support the findings of human studies, which suggest that both ketan and dox may exert beneficial effects on the erectile process.</description><identifier>ISSN: 0042-1138</identifier><identifier>EISSN: 1423-0399</identifier><identifier>DOI: 10.1159/000107959</identifier><identifier>PMID: 17940359</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adrenergic alpha-Antagonists - pharmacology ; Animals ; Dose-Response Relationship, Drug ; Enzyme Inhibitors - pharmacology ; In Vitro Techniques ; Male ; Muscle Contraction - drug effects ; Muscle Relaxation - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - enzymology ; Muscle, Smooth - metabolism ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - metabolism ; Original Paper ; Penile Erection - drug effects ; Penis - drug effects ; Penis - enzymology ; Penis - metabolism ; Rabbits ; Receptor, Serotonin, 5-HT2A - metabolism ; Receptors, Adrenergic, alpha - drug effects ; Receptors, Adrenergic, alpha - metabolism ; Receptors, Serotonin, 5-HT3 - metabolism ; Serotonin - metabolism ; Serotonin 5-HT2 Receptor Antagonists ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists - pharmacology</subject><ispartof>Urologia internationalis, 2007-01, Vol.79 (3), p.255-261</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>Copyright 2007 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-1c738521f70e3f4f42fe10e7387a9143491f68d3185a1ecc6bb801cfb2df30163</citedby><cites>FETCH-LOGICAL-c304t-1c738521f70e3f4f42fe10e7387a9143491f68d3185a1ecc6bb801cfb2df30163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17940359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lau, David H.W.</creatorcontrib><creatorcontrib>Thompson, Cecil S.</creatorcontrib><creatorcontrib>Mumtaz, Faiz H.</creatorcontrib><creatorcontrib>Morgan, Robert J.</creatorcontrib><creatorcontrib>Mikhailidis, Dimitri P.</creatorcontrib><title>Serotonin Induces a Biphasic Response in Rabbit Cavernosal Smooth Muscle: Relevance to the Erectile Process</title><title>Urologia internationalis</title><addtitle>Urol Int</addtitle><description>Introduction: Serotonin (5-hydroxytryptamine; 5-HT) can cause contraction in cavernosal smooth muscle. We further evaluated this effect of 5-HT. Methods: Organ bath studies were used. Results: 5-HT induced a sustained contraction occasionally accompanied by a transient relaxation (in 30% of rabbit cavernosal tissues) that preceded the contraction. Ondansetron and Y-25130 (both 5-HT 3 receptor antagonists) but not SB-269970 (a 5-HT 7 receptor antagonist) significantly inhibited or abolished this transient relaxation. Doxazosin (dox, an α 1 -receptor antagonist) and ketanserin (ketan, a 5-HT 2A receptor antagonist) significantly inhibited or abolished the sustained contraction. The effects of dox on 5-HT-mediated contraction were concentration-dependent. Conclusions: Our findings further confirm that the peripheral serotonergic pathway may play a part in the erectile process via 5-HT 2A receptor-mediated contractile and 5-HT 3 receptor-mediated relaxant activities. Our results also support the findings of human studies, which suggest that both ketan and dox may exert beneficial effects on the erectile process.</description><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - enzymology</subject><subject>Muscle, Smooth - metabolism</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Original Paper</subject><subject>Penile Erection - drug effects</subject><subject>Penis - drug effects</subject><subject>Penis - enzymology</subject><subject>Penis - metabolism</subject><subject>Rabbits</subject><subject>Receptor, Serotonin, 5-HT2A - metabolism</subject><subject>Receptors, Adrenergic, alpha - drug effects</subject><subject>Receptors, Adrenergic, alpha - metabolism</subject><subject>Receptors, Serotonin, 5-HT3 - metabolism</subject><subject>Serotonin - metabolism</subject><subject>Serotonin 5-HT2 Receptor Antagonists</subject><subject>Serotonin 5-HT3 Receptor Antagonists</subject><subject>Serotonin Antagonists - pharmacology</subject><issn>0042-1138</issn><issn>1423-0399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0D1PwzAQBmALgWgpDOwIeUJiCPhi58NsUBWoBAK1MEeOc6ahaRzspBL_nkArYDrp7rl3eAk5BnYBEMlLxhiwREZyhwxBhDxgXMpdMmRMhAEATwfkwPv3XkVSJvtkAIkUjEdySJZzdLa1dVnTaV10Gj1V9KZsFsqXms7QN7b2SPvzTOV52dKxWqOrrVcVna-sbRf0sfO6wqseV7hWtUbaWtoukE4c6raskD472wf7Q7JnVOXxaDtH5PV28jK-Dx6e7qbj64dAcybaAHTC0ygEkzDkRhgRGgSG_TJREgQXEkycFhzSSAFqHed5ykCbPCwMZxDzETnb5DbOfnTo22xVeo1VpWq0nc_iVLAo5GkPzzdQO-u9Q5M1rlwp95kBy76bzX6b7e3pNrTLV1j8yW2VPTjZgKVyb-j-Rf38fwF8W3wJ</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Lau, David H.W.</creator><creator>Thompson, Cecil S.</creator><creator>Mumtaz, Faiz H.</creator><creator>Morgan, Robert J.</creator><creator>Mikhailidis, Dimitri P.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Serotonin Induces a Biphasic Response in Rabbit Cavernosal Smooth Muscle: Relevance to the Erectile Process</title><author>Lau, David H.W. ; Thompson, Cecil S. ; Mumtaz, Faiz H. ; Morgan, Robert J. ; Mikhailidis, Dimitri P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-1c738521f70e3f4f42fe10e7387a9143491f68d3185a1ecc6bb801cfb2df30163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - enzymology</topic><topic>Muscle, Smooth - metabolism</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Original Paper</topic><topic>Penile Erection - drug effects</topic><topic>Penis - drug effects</topic><topic>Penis - enzymology</topic><topic>Penis - metabolism</topic><topic>Rabbits</topic><topic>Receptor, Serotonin, 5-HT2A - metabolism</topic><topic>Receptors, Adrenergic, alpha - drug effects</topic><topic>Receptors, Adrenergic, alpha - metabolism</topic><topic>Receptors, Serotonin, 5-HT3 - metabolism</topic><topic>Serotonin - metabolism</topic><topic>Serotonin 5-HT2 Receptor Antagonists</topic><topic>Serotonin 5-HT3 Receptor Antagonists</topic><topic>Serotonin Antagonists - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lau, David H.W.</creatorcontrib><creatorcontrib>Thompson, Cecil S.</creatorcontrib><creatorcontrib>Mumtaz, Faiz H.</creatorcontrib><creatorcontrib>Morgan, Robert J.</creatorcontrib><creatorcontrib>Mikhailidis, Dimitri P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urologia internationalis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lau, David H.W.</au><au>Thompson, Cecil S.</au><au>Mumtaz, Faiz H.</au><au>Morgan, Robert J.</au><au>Mikhailidis, Dimitri P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin Induces a Biphasic Response in Rabbit Cavernosal Smooth Muscle: Relevance to the Erectile Process</atitle><jtitle>Urologia internationalis</jtitle><addtitle>Urol Int</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>79</volume><issue>3</issue><spage>255</spage><epage>261</epage><pages>255-261</pages><issn>0042-1138</issn><eissn>1423-0399</eissn><abstract>Introduction: Serotonin (5-hydroxytryptamine; 5-HT) can cause contraction in cavernosal smooth muscle. We further evaluated this effect of 5-HT. Methods: Organ bath studies were used. Results: 5-HT induced a sustained contraction occasionally accompanied by a transient relaxation (in 30% of rabbit cavernosal tissues) that preceded the contraction. Ondansetron and Y-25130 (both 5-HT 3 receptor antagonists) but not SB-269970 (a 5-HT 7 receptor antagonist) significantly inhibited or abolished this transient relaxation. Doxazosin (dox, an α 1 -receptor antagonist) and ketanserin (ketan, a 5-HT 2A receptor antagonist) significantly inhibited or abolished the sustained contraction. The effects of dox on 5-HT-mediated contraction were concentration-dependent. Conclusions: Our findings further confirm that the peripheral serotonergic pathway may play a part in the erectile process via 5-HT 2A receptor-mediated contractile and 5-HT 3 receptor-mediated relaxant activities. Our results also support the findings of human studies, which suggest that both ketan and dox may exert beneficial effects on the erectile process.</abstract><cop>Basel, Switzerland</cop><pmid>17940359</pmid><doi>10.1159/000107959</doi><tpages>7</tpages></addata></record> |
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| subjects | Adrenergic alpha-Antagonists - pharmacology Animals Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology In Vitro Techniques Male Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - enzymology Muscle, Smooth - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Original Paper Penile Erection - drug effects Penis - drug effects Penis - enzymology Penis - metabolism Rabbits Receptor, Serotonin, 5-HT2A - metabolism Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - metabolism Receptors, Serotonin, 5-HT3 - metabolism Serotonin - metabolism Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT3 Receptor Antagonists Serotonin Antagonists - pharmacology |
| title | Serotonin Induces a Biphasic Response in Rabbit Cavernosal Smooth Muscle: Relevance to the Erectile Process |
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