Development of a spray congealing process for the preparation of insulin-loaded lipid microparticles and characterization thereof

A spray congealing process for the preparation of protein-loaded microparticles was developed. The influence of the process parameters atomization pressure and spraying temperature on particle size and process yield was investigated by experimental design. The employed spray congealing technique ena...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2007-02, Vol.65 (2), p.175-187
Hauptverfasser:	Maschke, Angelika, Becker, Christian, Eyrich, Daniela, Kiermaier, Josef, Blunk, Torsten, Göpferich, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cartilage - drug effects Cartilage - growth & development Cells, Cultured Chondrocytes - drug effects Controlled release Drug Compounding Experimental design General pharmacology Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Insulin Insulin - administration & dosage Insulin - chemistry Lipid microparticles Lipids Medical sciences Microspheres Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Protein Spray congealing Temperature Triglycerides Viscosity
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