Genetic instability syndromes with progeroid features

We discuss examples of the rare human genetic instability syndromes as they present themselves at the chromosome, telomere, and nuclear envelope level. Destabilization of the nuclear envelope due to mutations in the Lamin A/C gene lead to global impairments of the chromatin structure and gene expres...

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Veröffentlicht in:	Zeitschrift für Gerontologie und Geriatrie 2007-10, Vol.40 (5), p.339-348
Hauptverfasser:	Neveling, K, Bechtold, A, Hoehn, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging, Premature - genetics Chromosomal Instability - genetics Cockayne Syndrome - genetics Genetic Predisposition to Disease - genetics Genomic Instability - genetics Humans Models, Genetic Mutation Nuclear Envelope - genetics Nuclear Proteins - genetics Telomere - genetics
Online-Zugang:	Volltext
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