Ablation of undifferentiated human embryonic stem cells: exploiting innate immunity against the Gal alpha1-3Galbeta1-4GlcNAc-R (alpha-Gal) epitope

Although undifferentiated human embryonic stem cells (hESCs) are tumorigenic, this capacity is lost after differentiation, and hESCs are being widely investigated for applications in regenerative medicine. To engineer protection against the unintentional transplantation of undifferentiated cells, we...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2007-01, Vol.25 (1), p.10-18
Hauptverfasser:	Hewitt, Zoe, Priddle, Helen, Thomson, Alison J, Wojtacha, Davina, McWhir, Jim
Format:	Artikel
Sprache:	eng
Schlagworte:	ABO Blood-Group System Animals Cell Culture Techniques Cell Differentiation Cloning, Molecular DNA Primers Embryonic Stem Cells - cytology Embryonic Stem Cells - immunology Galactosyltransferases - genetics Humans Immunity, Innate Karyotyping Mice Mice, SCID Oligosaccharides - immunology Open Reading Frames Reference Values Transcription, Genetic Transfection
Online-Zugang:	Volltext
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