A bridging demineralized bone implant facilitates posterolateral lumbar fusion in New Zealand white rabbits
Randomized controlled animal study. Test the effectiveness of a single-strip demineralized bone matrix with hyaluronan and gelatin. Demineralized bone matrix is widely used to augment spinal fusion, however, the effect of changing the physical characteristic and carrier is not known. Demineralized b...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2007, Vol.32 (1), p.36-41 |
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| creator | CHOI, Yongsoo PARKE OLDENBURG, F SAGE, Latifa JOHNSTONE, Brian YOO, Jung U |
| description | Randomized controlled animal study.
Test the effectiveness of a single-strip demineralized bone matrix with hyaluronan and gelatin.
Demineralized bone matrix is widely used to augment spinal fusion, however, the effect of changing the physical characteristic and carrier is not known.
Demineralized bone matrix was extracted from the bones of New Zealand White rabbits, and combined with hyaluronan and gelatin to form solid strips. Forty-eight rabbits were randomized into a control and 2 experimental groups. In the control group, fusion was attempted with autograft bone. For group 2, demineralized bone matrix strips alone and for group 3, autograft and demineralized bone matrix strips were used. The fusion was assessed with manual manipulation and radiographs. The volume of the fusion mass was determined from computed tomographic images.
By the manual palpation test, the fusion rates were 37.5%, 93.8%, and 100%, for groups 1-3, respectively (P < 0.05). By radiography, the control group fusion rate was 68.7% compared with 100% for the experimental groups (P < 0.05). The mean bone volumes of the fusion mass were 2142.2 +/- 318.5, 3132.9 +/- 632.1, and 4181.6 +/- 609.5 mm3 for groups 1-3, respectively (P < 0.05).
The demineralized bone matrix-gel strip was able to function as both a bone-graft enhancer and a bone graft substitute in rabbit posterolateral spine fusion. |
| doi_str_mv | 10.1097/01.brs.0000250982.41666.55 |
| format | Article |
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Test the effectiveness of a single-strip demineralized bone matrix with hyaluronan and gelatin.
Demineralized bone matrix is widely used to augment spinal fusion, however, the effect of changing the physical characteristic and carrier is not known.
Demineralized bone matrix was extracted from the bones of New Zealand White rabbits, and combined with hyaluronan and gelatin to form solid strips. Forty-eight rabbits were randomized into a control and 2 experimental groups. In the control group, fusion was attempted with autograft bone. For group 2, demineralized bone matrix strips alone and for group 3, autograft and demineralized bone matrix strips were used. The fusion was assessed with manual manipulation and radiographs. The volume of the fusion mass was determined from computed tomographic images.
By the manual palpation test, the fusion rates were 37.5%, 93.8%, and 100%, for groups 1-3, respectively (P < 0.05). By radiography, the control group fusion rate was 68.7% compared with 100% for the experimental groups (P < 0.05). The mean bone volumes of the fusion mass were 2142.2 +/- 318.5, 3132.9 +/- 632.1, and 4181.6 +/- 609.5 mm3 for groups 1-3, respectively (P < 0.05).
The demineralized bone matrix-gel strip was able to function as both a bone-graft enhancer and a bone graft substitute in rabbit posterolateral spine fusion.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/01.brs.0000250982.41666.55</identifier><identifier>PMID: 17202890</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Bone Demineralization Technique - methods ; Bone Matrix - transplantation ; Bone Transplantation - methods ; Cerebrospinal fluid. Meninges. Spinal cord ; Diseases of the osteoarticular system ; Diseases of the spine ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - surgery ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Orthopedic surgery ; Rabbits ; Radiography ; Spinal Fusion - methods ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2007, Vol.32 (1), p.36-41</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-6c6b87242edb795826f10999069682dcaefb8883ca49ad121104c1ddd18b6fdd3</citedby><cites>FETCH-LOGICAL-c378t-6c6b87242edb795826f10999069682dcaefb8883ca49ad121104c1ddd18b6fdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18430131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17202890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHOI, Yongsoo</creatorcontrib><creatorcontrib>PARKE OLDENBURG, F</creatorcontrib><creatorcontrib>SAGE, Latifa</creatorcontrib><creatorcontrib>JOHNSTONE, Brian</creatorcontrib><creatorcontrib>YOO, Jung U</creatorcontrib><title>A bridging demineralized bone implant facilitates posterolateral lumbar fusion in New Zealand white rabbits</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>Randomized controlled animal study.
Test the effectiveness of a single-strip demineralized bone matrix with hyaluronan and gelatin.
Demineralized bone matrix is widely used to augment spinal fusion, however, the effect of changing the physical characteristic and carrier is not known.
Demineralized bone matrix was extracted from the bones of New Zealand White rabbits, and combined with hyaluronan and gelatin to form solid strips. Forty-eight rabbits were randomized into a control and 2 experimental groups. In the control group, fusion was attempted with autograft bone. For group 2, demineralized bone matrix strips alone and for group 3, autograft and demineralized bone matrix strips were used. The fusion was assessed with manual manipulation and radiographs. The volume of the fusion mass was determined from computed tomographic images.
By the manual palpation test, the fusion rates were 37.5%, 93.8%, and 100%, for groups 1-3, respectively (P < 0.05). By radiography, the control group fusion rate was 68.7% compared with 100% for the experimental groups (P < 0.05). The mean bone volumes of the fusion mass were 2142.2 +/- 318.5, 3132.9 +/- 632.1, and 4181.6 +/- 609.5 mm3 for groups 1-3, respectively (P < 0.05).
The demineralized bone matrix-gel strip was able to function as both a bone-graft enhancer and a bone graft substitute in rabbit posterolateral spine fusion.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Demineralization Technique - methods</subject><subject>Bone Matrix - transplantation</subject><subject>Bone Transplantation - methods</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Orthopedic surgery</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Spinal Fusion - methods</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9rb6FyQIdjfTnGSSSdyV0lqh1I1u3IR8nKnR-bgmMxT99UZ74S7N5hB43uSc8xDyFlgLzPQXDFqfS8vq4ZIZzdsOlFKtlM_IDiTXDYA0z8mOCcUb3gl1Qk5L-V55JcC8JCfQc8a1YTvy45L6nOJDmh9oxCnNmN2YfmOkfpmRpmk_unmlgwtpTKtbsdD9UlbMy1gvlaXjNnmX6bCVtMw0zfQeH-lXdDUX6eO3tCLNzvu0llfkxeDGgq8P9Yx8ubn-fHXb3H368PHq8q4Jotdro4Lyuucdx-h7IzVXQx3bGKaM0jwGh4PXWovgOuMicADWBYgxgvZqiFGckfOnd_d5-blhWe2USsCxdoTLVqzSHeskg_-CYIyumxQVfP8EhryUknGw-5wml39ZYPavE8vAVif26MT-c2KlrOE3h182P2E8Rg8SKvDuALgS3DhkN4dUjpzuRG0WxB9565cm</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>CHOI, Yongsoo</creator><creator>PARKE OLDENBURG, F</creator><creator>SAGE, Latifa</creator><creator>JOHNSTONE, Brian</creator><creator>YOO, Jung U</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>A bridging demineralized bone implant facilitates posterolateral lumbar fusion in New Zealand white rabbits</title><author>CHOI, Yongsoo ; PARKE OLDENBURG, F ; SAGE, Latifa ; JOHNSTONE, Brian ; YOO, Jung U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-6c6b87242edb795826f10999069682dcaefb8883ca49ad121104c1ddd18b6fdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Demineralization Technique - methods</topic><topic>Bone Matrix - transplantation</topic><topic>Bone Transplantation - methods</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Orthopedic surgery</topic><topic>Rabbits</topic><topic>Radiography</topic><topic>Spinal Fusion - methods</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHOI, Yongsoo</creatorcontrib><creatorcontrib>PARKE OLDENBURG, F</creatorcontrib><creatorcontrib>SAGE, Latifa</creatorcontrib><creatorcontrib>JOHNSTONE, Brian</creatorcontrib><creatorcontrib>YOO, Jung U</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHOI, Yongsoo</au><au>PARKE OLDENBURG, F</au><au>SAGE, Latifa</au><au>JOHNSTONE, Brian</au><au>YOO, Jung U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A bridging demineralized bone implant facilitates posterolateral lumbar fusion in New Zealand white rabbits</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2007</date><risdate>2007</risdate><volume>32</volume><issue>1</issue><spage>36</spage><epage>41</epage><pages>36-41</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>Randomized controlled animal study.
Test the effectiveness of a single-strip demineralized bone matrix with hyaluronan and gelatin.
Demineralized bone matrix is widely used to augment spinal fusion, however, the effect of changing the physical characteristic and carrier is not known.
Demineralized bone matrix was extracted from the bones of New Zealand White rabbits, and combined with hyaluronan and gelatin to form solid strips. Forty-eight rabbits were randomized into a control and 2 experimental groups. In the control group, fusion was attempted with autograft bone. For group 2, demineralized bone matrix strips alone and for group 3, autograft and demineralized bone matrix strips were used. The fusion was assessed with manual manipulation and radiographs. The volume of the fusion mass was determined from computed tomographic images.
By the manual palpation test, the fusion rates were 37.5%, 93.8%, and 100%, for groups 1-3, respectively (P < 0.05). By radiography, the control group fusion rate was 68.7% compared with 100% for the experimental groups (P < 0.05). The mean bone volumes of the fusion mass were 2142.2 +/- 318.5, 3132.9 +/- 632.1, and 4181.6 +/- 609.5 mm3 for groups 1-3, respectively (P < 0.05).
The demineralized bone matrix-gel strip was able to function as both a bone-graft enhancer and a bone graft substitute in rabbit posterolateral spine fusion.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>17202890</pmid><doi>10.1097/01.brs.0000250982.41666.55</doi><tpages>6</tpages></addata></record> |
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| ispartof | Spine (Philadelphia, Pa. 1976), 2007, Vol.32 (1), p.36-41 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Bone Demineralization Technique - methods Bone Matrix - transplantation Bone Transplantation - methods Cerebrospinal fluid. Meninges. Spinal cord Diseases of the osteoarticular system Diseases of the spine Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - surgery Medical sciences Nervous system (semeiology, syndromes) Neurology Orthopedic surgery Rabbits Radiography Spinal Fusion - methods Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
| title | A bridging demineralized bone implant facilitates posterolateral lumbar fusion in New Zealand white rabbits |
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