Inhibition of horseradish peroxidase catalytic activity by new 3-phenylcoumarin derivatives: Synthesis and structure–activity relationships

Twenty hydroxylated and acetoxylated 3-phenylcoumarins were synthesized, and the structure–activity relationships were investigated by evaluating the ability of these compounds to modulate horseradish peroxidase (HRP) catalytic activity and comparing the results to four flavonoids (quercetin, myrice...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-02, Vol.15 (3), p.1516-1524
Hauptverfasser:	Kabeya, Luciana M., de Marchi, Anderson A., Kanashiro, Alexandre, Lopes, Norberto P., da Silva, Carlos H.T.P., Pupo, Mônica T., Lucisano-Valim, Yara M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Catechol Coumarin Coumarins - chemical synthesis Coumarins - chemistry Coumarins - pharmacology Docking Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes and enzyme inhibitors Free Radical Scavengers - chemical synthesis Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Fundamental and applied biological sciences. Psychology General and cellular metabolism. Vitamins Horseradish peroxidase Horseradish Peroxidase - antagonists & inhibitors Medical sciences Models, Molecular Molecular Structure Oxidoreductases Pharmacology. Drug treatments Structure-Activity Relationship
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