Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding properties

Pyrrolidine-amide oligonucleotide mimics (POMs) exhibit promising properties for potential applications, including in vivo DNA and RNA targeting, diagnostics and bioanalysis. Before POMs can be evaluated in these applications it is first necessary to synthesise and establish the properties of fully...

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Veröffentlicht in:	Organic & biomolecular chemistry 2007-01, Vol.5 (2), p.249-259
Hauptverfasser:	Worthington, Roberta J, O'Rourke, Adam P, Morral, Jordi, Tan, T H Samuel, Micklefield, Jason
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Crystallography, X-Ray DNA - chemistry Hot Temperature Models, Chemical Nucleic Acid Denaturation Nucleic Acids - chemistry Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Peptide Nucleic Acids - chemistry Pyrrolidines - chemistry RNA - chemistry Temperature Ultraviolet Rays
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