The Complex Immunology of Human Coccidioidomycosis
: The human immune response during coccidioidomycosis is intimately involved with the development of delayed‐type hypersensitivity and cellular immunity. Sixty percent of those infected have no symptoms and benign outcome is generally associated with a specific cellular immune response to coccidioi...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2007-09, Vol.1111 (1), p.245-258 |
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| creator | AMPEL, NEIL M. |
| description | : The human immune response during coccidioidomycosis is intimately involved with the development of delayed‐type hypersensitivity and cellular immunity. Sixty percent of those infected have no symptoms and benign outcome is generally associated with a specific cellular immune response to coccidioidal antigens. We have recently teased out the human pulmonary granulomatous response during coccidioidomycosis and noted that there are perigranulomatous clusters of lymphocytes consisting predominantly of B lymphocytes and CD4+ T lymphocytes. In other work, we have found that the mannose receptor as well as the toll‐like receptors TLR2 and TLR4 may have a role in recognizing glycosylated coccidioidal antigens. In addition, the IL‐12 receptor axis appears to be operative during antigen recognition and IL‐12p40 may be the active moiety. Finally, peripheral blood mononuclear cells from persons with disseminated coccidioidomycosis are able to respond to coccidioidal antigen when it is presented by a mature monocyte‐derived IL‐4‐generated dendritic cell (DC). These observations could be useful in the development of a human vaccine against coccidiodomycosis. |
| doi_str_mv | 10.1196/annals.1406.032 |
| format | Article |
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Sixty percent of those infected have no symptoms and benign outcome is generally associated with a specific cellular immune response to coccidioidal antigens. We have recently teased out the human pulmonary granulomatous response during coccidioidomycosis and noted that there are perigranulomatous clusters of lymphocytes consisting predominantly of B lymphocytes and CD4+ T lymphocytes. In other work, we have found that the mannose receptor as well as the toll‐like receptors TLR2 and TLR4 may have a role in recognizing glycosylated coccidioidal antigens. In addition, the IL‐12 receptor axis appears to be operative during antigen recognition and IL‐12p40 may be the active moiety. Finally, peripheral blood mononuclear cells from persons with disseminated coccidioidomycosis are able to respond to coccidioidal antigen when it is presented by a mature monocyte‐derived IL‐4‐generated dendritic cell (DC). These observations could be useful in the development of a human vaccine against coccidiodomycosis.</description><subject>B-Lymphocytes - microbiology</subject><subject>CD4-Positive T-Lymphocytes - microbiology</subject><subject>cellular immunity</subject><subject>coccidioidomycosis</subject><subject>Coccidioidomycosis - diagnosis</subject><subject>Coccidioidomycosis - epidemiology</subject><subject>Coccidioidomycosis - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Gene Expression Regulation, Fungal</subject><subject>human</subject><subject>Humans</subject><subject>Immune System</subject><subject>Interferon-gamma - metabolism</subject><subject>Monocytes - metabolism</subject><subject>Toll-Like Receptor 2 - physiology</subject><subject>Toll-Like Receptor 4 - physiology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0077-8923</issn><issn>1749-6632</issn><issn>1930-6547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9PwjAYhhujEUTP3gwnb4P-WNv1aIgCETFRjPHUdF2n1XXFlUX23zsyokd6-Q593udrXwAuERwhJNhYlaUqwgjFkI0gwUegj3gsIsYIPgZ9CDmPEoFJD5yF8AkhwknMT0EPccJITHAf4NWHGU68WxdmO5w7V5e-8O_N0OfDWe1U2d5pbTPrbeZdo32w4Ryc5O1Sc7GfA_Byd7uazKLF43Q-uVlEOkYERwnFmCQGxjnNkFYpzBmmxGTts6EWFGGdaEZzmKFUp0IJyFOCUsRzoaBgnJABuO6868p_1yZspLNBm6JQpfF1kCyJISYUHwQxpALHdGccd6CufAiVyeW6sk5VjURQ7vqUXZ9y16ds-2wTV3t1nTqT_fP7Alsg6YAfW5jmkE8u326eUXs6d9RFbdiY7V9UVV-y_T6n8nU5lavl4uH-iRJJyC_CoJDz</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>AMPEL, NEIL M.</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>The Complex Immunology of Human Coccidioidomycosis</title><author>AMPEL, NEIL M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4132-852238e04f5d1cab0f6253ed1960c9512c8c65f0d1bcb9a907b31b17f9a096733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>B-Lymphocytes - microbiology</topic><topic>CD4-Positive T-Lymphocytes - microbiology</topic><topic>cellular immunity</topic><topic>coccidioidomycosis</topic><topic>Coccidioidomycosis - diagnosis</topic><topic>Coccidioidomycosis - epidemiology</topic><topic>Coccidioidomycosis - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Gene Expression Regulation, Fungal</topic><topic>human</topic><topic>Humans</topic><topic>Immune System</topic><topic>Interferon-gamma - metabolism</topic><topic>Monocytes - metabolism</topic><topic>Toll-Like Receptor 2 - physiology</topic><topic>Toll-Like Receptor 4 - physiology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AMPEL, NEIL M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AMPEL, NEIL M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Complex Immunology of Human Coccidioidomycosis</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2007-09</date><risdate>2007</risdate><volume>1111</volume><issue>1</issue><spage>245</spage><epage>258</epage><pages>245-258</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><eissn>1930-6547</eissn><abstract>: The human immune response during coccidioidomycosis is intimately involved with the development of delayed‐type hypersensitivity and cellular immunity. Sixty percent of those infected have no symptoms and benign outcome is generally associated with a specific cellular immune response to coccidioidal antigens. We have recently teased out the human pulmonary granulomatous response during coccidioidomycosis and noted that there are perigranulomatous clusters of lymphocytes consisting predominantly of B lymphocytes and CD4+ T lymphocytes. In other work, we have found that the mannose receptor as well as the toll‐like receptors TLR2 and TLR4 may have a role in recognizing glycosylated coccidioidal antigens. In addition, the IL‐12 receptor axis appears to be operative during antigen recognition and IL‐12p40 may be the active moiety. Finally, peripheral blood mononuclear cells from persons with disseminated coccidioidomycosis are able to respond to coccidioidal antigen when it is presented by a mature monocyte‐derived IL‐4‐generated dendritic cell (DC). These observations could be useful in the development of a human vaccine against coccidiodomycosis.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17363432</pmid><doi>10.1196/annals.1406.032</doi><tpages>14</tpages></addata></record> |
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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2007-09, Vol.1111 (1), p.245-258 |
| issn | 0077-8923 1749-6632 1930-6547 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | B-Lymphocytes - microbiology CD4-Positive T-Lymphocytes - microbiology cellular immunity coccidioidomycosis Coccidioidomycosis - diagnosis Coccidioidomycosis - epidemiology Coccidioidomycosis - immunology Dendritic Cells - metabolism Gene Expression Regulation, Fungal human Humans Immune System Interferon-gamma - metabolism Monocytes - metabolism Toll-Like Receptor 2 - physiology Toll-Like Receptor 4 - physiology Tumor Necrosis Factor-alpha - metabolism |
| title | The Complex Immunology of Human Coccidioidomycosis |
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