An orthotopic xenograft model of intraneural NF1 MPNST suggests a potential association between steroid hormones and tumor cell proliferation

Malignant peripheral nerve sheath tumors (MPNST) are the most aggressive cancers associated with neurofibromatosis type 1 (NF1). Here we report a practical and reproducible model of intraneural NF1 MPNST, by orthotopic xenograft of an immortal human NF1 tumor-derived Schwann cell line into the sciat...

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Veröffentlicht in:	Laboratory investigation 2007-11, Vol.87 (11), p.1092-1102
Hauptverfasser:	Perrin, George Q, Li, Hua, Fishbein, Lauren, Thomson, Susanne A, Hwang, Min S, Scarborough, Mark T, Yachnis, Anthony T, Wallace, Margaret R, Mareci, Thomas H, Muir, David
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Biological and medical sciences Biotechnology Cell Line, Tumor Cell Proliferation Estrogens - physiology Female Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Magnetic Resonance Imaging malignant peripheral nerve sheath tumor Mast Cells Medical sciences Medicine Medicine & Public Health Mice Mice, SCID Neoplasm Transplantation Neovascularization, Pathologic - metabolism Nerve Sheath Neoplasms - blood supply Nerve Sheath Neoplasms - metabolism Nerve Sheath Neoplasms - pathology neurofibromatosis Neurofibromatosis 1 - metabolism Neurofibromatosis 1 - pathology Neurofibromin 1 - physiology orthotopic Ovariectomy Pathology Peripheral Nervous System Neoplasms - blood supply Peripheral Nervous System Neoplasms - metabolism Peripheral Nervous System Neoplasms - pathology Progesterone - physiology research-article Schwann Cells - pathology Sciatic Nerve - metabolism Sciatic Nerve - pathology steroid hormone Transplantation, Heterologous xenografts
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