Cytokine and Chemokine Expression in Humans Infected with Sudan Ebola Virus
The size and duration of the 2000 outbreak of Sudan Ebola virus (SEBOV) infection in Uganda made it possible to collect serial serum samples from 87 patients (53 survivors and 34 nonsurvivors). Surprisingly, the levels of tumor necrosis factor-α and interferon (IFN)-γ, which had been found to be inc...
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| Veröffentlicht in: | The Journal of infectious diseases 2007-11, Vol.196 (Supplement-2), p.S357-S363 |
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| container_title | The Journal of infectious diseases |
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| creator | Hutchinson, Karen L. Rollin, Pierre E. |
| description | The size and duration of the 2000 outbreak of Sudan Ebola virus (SEBOV) infection in Uganda made it possible to collect serial serum samples from 87 patients (53 survivors and 34 nonsurvivors). Surprisingly, the levels of tumor necrosis factor-α and interferon (IFN)-γ, which had been found to be increased in patients with fatal Zaire Ebola virus infection, were not increased in any of the patients with SEBOV infection. The levels of interleukin (IL)-1β, IFN-γ-inducible protein-10, and RANTES (regulated on activation, normally T cell-expressed and —secreted) were higher in samples from all patients with SEBOV infection than in control samples from healthy hospital staff members, but their levels did not differ between those who survived and those who did not. The levels of IFN-α were significantly higher in surviving patients with SEBOV infection, whereas the levels of IL-6, IL-8, IL-10, and macrophage inflammatory protein-1β were higher in patients with fatal SEBOV infections. |
| doi_str_mv | 10.1086/520611 |
| format | Article |
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Surprisingly, the levels of tumor necrosis factor-α and interferon (IFN)-γ, which had been found to be increased in patients with fatal Zaire Ebola virus infection, were not increased in any of the patients with SEBOV infection. The levels of interleukin (IL)-1β, IFN-γ-inducible protein-10, and RANTES (regulated on activation, normally T cell-expressed and —secreted) were higher in samples from all patients with SEBOV infection than in control samples from healthy hospital staff members, but their levels did not differ between those who survived and those who did not. The levels of IFN-α were significantly higher in surviving patients with SEBOV infection, whereas the levels of IL-6, IL-8, IL-10, and macrophage inflammatory protein-1β were higher in patients with fatal SEBOV infections.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/520611</identifier><identifier>PMID: 17940971</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Antibodies ; Antibodies, Viral - blood ; Biological and medical sciences ; Chemokines ; Chemokines - blood ; Cytokines ; Cytokines - blood ; Disease Outbreaks ; Ebola virus ; Ebolavirus - genetics ; Fundamental and applied biological sciences. Psychology ; Hemorrhagic Fever, Ebola - blood ; Hemorrhagic Fever, Ebola - immunology ; Hemorrhagic Fever, Ebola - mortality ; Humans ; Infections ; Interferon-alpha - blood ; Interferon-gamma - blood ; Interferons ; Microbiology ; Miscellaneous ; Pathogenesis ; Survival Analysis ; Survivors ; Time Factors ; Tumor Necrosis Factor-alpha - blood ; Uganda - epidemiology ; Viral Pathogenesis ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2007-11, Vol.196 (Supplement-2), p.S357-S363</ispartof><rights>Copyright 2007 Infectious Diseases Society of America</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-3ecd132bfe49f722be47d44cbf636583cc69e0f965624b48216d217d08f2b5513</citedby><cites>FETCH-LOGICAL-c430t-3ecd132bfe49f722be47d44cbf636583cc69e0f965624b48216d217d08f2b5513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30086777$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30086777$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,799,23909,23910,25118,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19881273$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17940971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hutchinson, Karen L.</creatorcontrib><creatorcontrib>Rollin, Pierre E.</creatorcontrib><title>Cytokine and Chemokine Expression in Humans Infected with Sudan Ebola Virus</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>The size and duration of the 2000 outbreak of Sudan Ebola virus (SEBOV) infection in Uganda made it possible to collect serial serum samples from 87 patients (53 survivors and 34 nonsurvivors). Surprisingly, the levels of tumor necrosis factor-α and interferon (IFN)-γ, which had been found to be increased in patients with fatal Zaire Ebola virus infection, were not increased in any of the patients with SEBOV infection. The levels of interleukin (IL)-1β, IFN-γ-inducible protein-10, and RANTES (regulated on activation, normally T cell-expressed and —secreted) were higher in samples from all patients with SEBOV infection than in control samples from healthy hospital staff members, but their levels did not differ between those who survived and those who did not. The levels of IFN-α were significantly higher in surviving patients with SEBOV infection, whereas the levels of IL-6, IL-8, IL-10, and macrophage inflammatory protein-1β were higher in patients with fatal SEBOV infections.</description><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Chemokines</subject><subject>Chemokines - blood</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Disease Outbreaks</subject><subject>Ebola virus</subject><subject>Ebolavirus - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemorrhagic Fever, Ebola - blood</subject><subject>Hemorrhagic Fever, Ebola - immunology</subject><subject>Hemorrhagic Fever, Ebola - mortality</subject><subject>Humans</subject><subject>Infections</subject><subject>Interferon-alpha - blood</subject><subject>Interferon-gamma - blood</subject><subject>Interferons</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Pathogenesis</subject><subject>Survival Analysis</subject><subject>Survivors</subject><subject>Time Factors</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Uganda - epidemiology</subject><subject>Viral Pathogenesis</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1P3DAQBmALtYKFwj9o5Qu9pR1_xI6P1bJlUVctUluEuFiOYwtD4ix2osK_b6qslmNPo9H7aEZ6EToj8IlAJT6XFAQhB2hBSiYLIQh7gxYAlBakUuoIHef8AACcCXmIjohUHJQkC_Rt-TL0jyE6bGKDl_eum7fV8za5nEMfcYh4PXYmZnwVvbODa_CfMNzjn2NjIl7VfWvwTUhjfofeetNmd7qbJ-j319Wv5brY_Li8Wn7ZFJYzGArmbEMYrb3jyktKa8dlw7mtvWCirJi1QjnwSpSC8ppXlIiGEtlA5WldloSdoI_z3W3qn0aXB92FbF3bmuj6MWtRcSC05P-FFBQINb3cQ5v6nJPzeptCZ9KLJqD_9avnfif4YXdxrDvXvLJdoRM43wGTrWl9MtGG_OpUVREq2eTez-4hD33a5wymZ1LKKS_mPOTBPe9zkx61kEyWen17pzeb2wt2fc30d_YXpMaYcw</recordid><startdate>20071115</startdate><enddate>20071115</enddate><creator>Hutchinson, Karen L.</creator><creator>Rollin, Pierre E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20071115</creationdate><title>Cytokine and Chemokine Expression in Humans Infected with Sudan Ebola Virus</title><author>Hutchinson, Karen L. ; Rollin, Pierre E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-3ecd132bfe49f722be47d44cbf636583cc69e0f965624b48216d217d08f2b5513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Chemokines</topic><topic>Chemokines - blood</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Disease Outbreaks</topic><topic>Ebola virus</topic><topic>Ebolavirus - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemorrhagic Fever, Ebola - blood</topic><topic>Hemorrhagic Fever, Ebola - immunology</topic><topic>Hemorrhagic Fever, Ebola - mortality</topic><topic>Humans</topic><topic>Infections</topic><topic>Interferon-alpha - blood</topic><topic>Interferon-gamma - blood</topic><topic>Interferons</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Pathogenesis</topic><topic>Survival Analysis</topic><topic>Survivors</topic><topic>Time Factors</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Uganda - epidemiology</topic><topic>Viral Pathogenesis</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hutchinson, Karen L.</creatorcontrib><creatorcontrib>Rollin, Pierre E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hutchinson, Karen L.</au><au>Rollin, Pierre E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine and Chemokine Expression in Humans Infected with Sudan Ebola Virus</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2007-11-15</date><risdate>2007</risdate><volume>196</volume><issue>Supplement-2</issue><spage>S357</spage><epage>S363</epage><pages>S357-S363</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The size and duration of the 2000 outbreak of Sudan Ebola virus (SEBOV) infection in Uganda made it possible to collect serial serum samples from 87 patients (53 survivors and 34 nonsurvivors). Surprisingly, the levels of tumor necrosis factor-α and interferon (IFN)-γ, which had been found to be increased in patients with fatal Zaire Ebola virus infection, were not increased in any of the patients with SEBOV infection. The levels of interleukin (IL)-1β, IFN-γ-inducible protein-10, and RANTES (regulated on activation, normally T cell-expressed and —secreted) were higher in samples from all patients with SEBOV infection than in control samples from healthy hospital staff members, but their levels did not differ between those who survived and those who did not. The levels of IFN-α were significantly higher in surviving patients with SEBOV infection, whereas the levels of IL-6, IL-8, IL-10, and macrophage inflammatory protein-1β were higher in patients with fatal SEBOV infections.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>17940971</pmid><doi>10.1086/520611</doi><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Antibodies Antibodies, Viral - blood Biological and medical sciences Chemokines Chemokines - blood Cytokines Cytokines - blood Disease Outbreaks Ebola virus Ebolavirus - genetics Fundamental and applied biological sciences. Psychology Hemorrhagic Fever, Ebola - blood Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - mortality Humans Infections Interferon-alpha - blood Interferon-gamma - blood Interferons Microbiology Miscellaneous Pathogenesis Survival Analysis Survivors Time Factors Tumor Necrosis Factor-alpha - blood Uganda - epidemiology Viral Pathogenesis Virology Viruses |
| title | Cytokine and Chemokine Expression in Humans Infected with Sudan Ebola Virus |
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