The Regulation of Cellular Iron Metabolism

While iron is an essential trace element required by nearly all living organisms, deficiencies or excesses can lead to pathological conditions such as iron deficiency anemia or hemochromatosis, respectively. A decade has passed since the discovery of the hemochromatosis gene, HFE, and our understand...

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Veröffentlicht in:	Critical reviews in clinical laboratory sciences 2007-01, Vol.44 (5-6), p.413-459
Hauptverfasser:	Chua, Anita C. G., Graham, Ross M., Trinder, Debbie, Olynyk, John K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Iron-Deficiency - metabolism Animals Antimicrobial Cationic Peptides - metabolism Biological Transport Cation Transport Proteins - metabolism Ceruloplasmin - metabolism GPI-Linked Proteins Hemochromatosis - genetics Hemochromatosis Protein hepcidin Hepcidins HFE Histocompatibility Antigens Class I - metabolism Humans Intestinal Absorption iron Iron - metabolism Iron Metabolism Disorders - genetics Iron Overload - metabolism Iron, Dietary - pharmacokinetics Iron-Binding Proteins - genetics Iron-Binding Proteins - metabolism liver Liver - metabolism Membrane Proteins - metabolism Mutation - genetics Receptors, Transferrin - deficiency Receptors, Transferrin - genetics Receptors, Transferrin - metabolism Transferrin - deficiency Transferrin - genetics Transferrin - metabolism transferrin receptors
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