The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors

Caffeine produces effects on cognitive function particularly relating to aspects of attention such as reaction time. Considering the plasma exposure levels following regular caffeine intake, and the affinity of caffeine for known protein targets, these effects are likely mediated by either the adeno...

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Veröffentlicht in:	Behavioural brain research 2007-12, Vol.185 (1), p.32-42
Hauptverfasser:	Higgins, Guy A, Grzelak, Michael E, Pond, Annamarie J, Cohen-Williams, Mary E, Hodgson, Robert A, Varty, Geoffrey B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine A2 Receptor Antagonists Amphetamine - pharmacology Animals Antipsychotic Agents - pharmacology Attention - drug effects Caffeine - pharmacology Central Nervous System Stimulants - pharmacology Choice Behavior - drug effects Dopamine - physiology Dose-Response Relationship, Drug Male Motor Activity - drug effects Phenethylamines - pharmacology Psychomotor Performance - drug effects Purines - pharmacology Rats Reaction Time - drug effects Reflex, Startle - drug effects Xanthines - pharmacology
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