Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells

Arsenic trioxide (As2O3) has been approved for the treatment of acute promyelocytic leukemia (APML) and it is a promising candidate for the treatment of patients with lymphoproliferative disorders, such as relapsed or refractory multiple myeloma and myelodysplastic syndromes. The effects of As2O3 on...

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Veröffentlicht in:	International journal of oncology 2007-02, Vol.30 (2), p.313-318
Hauptverfasser:	BAYSAN, Abdullah, YEL, Leman, GOLLAPUDI, Sastry, HOUFEN SU, GUPTA, Sudhir
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Apoptosis Inducing Factor - metabolism Apoptosis Regulatory Proteins - biosynthesis Arsenicals - pharmacology B-Lymphocytes - metabolism bcl-2-Associated X Protein - biosynthesis Bcl-2-Like Protein 11 Biological and medical sciences Cytochromes c - metabolism Cytoplasm - metabolism Humans Leukemia, Promyelocytic, Acute - metabolism Male Medical sciences Membrane Potentials Membrane Proteins - biosynthesis Mitochondria - metabolism Oxidative Stress Oxides - pharmacology Proto-Oncogene Proteins - biosynthesis Tumors Up-Regulation
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