CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-γ production, and macrophage accumulation in the aortic wall

T lymphocytes are thought to be important in atherosclerosis, but very little is known about the mechanisms of lymphocyte recruitment into atherosclerosis-prone aortas. In this study we tested the hypothesis that CXCR6, a chemokine receptor that is expressed on a subset of CD4+ T helper 1 cells and...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2007-10, Vol.116 (16), p.1801-1811
Hauptverfasser:	GALKINA, Elena, HARRY, Brian L, LUDWIG, Andreas, LIEHN, Elisa A, SANDERS, John M, BRUCE, Anthony, WEBER, Christian, LEY, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Diseases - immunology Aortic Diseases - pathology Aortic Diseases - physiopathology Apolipoproteins E - genetics Atherosclerosis - immunology Atherosclerosis - pathology Atherosclerosis - physiopathology Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Diseases of the aorta Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - genetics Humans Interferon-gamma - metabolism Macrophages - immunology Macrophages - pathology Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Protein Transport - immunology Receptors, CXCR - genetics Receptors, CXCR - immunology Receptors, CXCR6 T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology Vertebrates: cardiovascular system
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