Oxygen content of transmembrane proteins over macroevolutionary time scales
We observe that the time of appearance of cellular compartmentalization correlates with atmospheric oxygen concentration. To explore this correlation, we predict and characterize the topology of all transmembrane proteins in 19 taxa and correlate differences in topology with historical atmospheric o...
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| Veröffentlicht in: | Nature (London) 2007-01, Vol.445 (7123), p.47-52 |
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| creator | Kleffe, Jürgen Acquisti, Claudia Collins, Sinéad |
| description | We observe that the time of appearance of cellular compartmentalization correlates with atmospheric oxygen concentration. To explore this correlation, we predict and characterize the topology of all transmembrane proteins in 19 taxa and correlate differences in topology with historical atmospheric oxygen concentrations. Here we show that transmembrane proteins, individually and as a group, were probably selectively excluding oxygen in ancient ancestral taxa, and that this constraint decreased over time when atmospheric oxygen levels rose. As this constraint decreased, the size and number of communication-related transmembrane proteins increased. We suggest the hypothesis that atmospheric oxygen concentrations affected the timing of the evolution of cellular compartmentalization by constraining the size of domains necessary for communication across membranes.
Coming up for air
Fossils are conventionally used to trace evolutionary change over time. But we may also preserve our history in our biochemistry. Claudia Acquisti
et al
. have discovered systematic variation in the ways in which various organisms incorporate oxygen into membrane-spanning proteins. Membrane proteins in compartmentalized prokaryotes and eukaryotes tend to contain more oxygen than those of simpler prokaryotes. This may be an echo of the low atmospheric oxygen on the early Earth. |
| doi_str_mv | 10.1038/nature05450 |
| format | Article |
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Coming up for air
Fossils are conventionally used to trace evolutionary change over time. But we may also preserve our history in our biochemistry. Claudia Acquisti
et al
. have discovered systematic variation in the ways in which various organisms incorporate oxygen into membrane-spanning proteins. Membrane proteins in compartmentalized prokaryotes and eukaryotes tend to contain more oxygen than those of simpler prokaryotes. This may be an echo of the low atmospheric oxygen on the early Earth.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature05450</identifier><identifier>PMID: 17183269</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Atmosphere - chemistry ; Atmospheric chemistry ; Biological and medical sciences ; Biological evolution ; Cell Compartmentation - physiology ; Cell Membrane - metabolism ; Eukaryotic Cells - metabolism ; Evolution, Molecular ; Evolutionary biology ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Humanities and Social Sciences ; Intracellular Membranes - metabolism ; Membrane Proteins - chemistry ; Membrane Proteins - metabolism ; Models, Biological ; multidisciplinary ; Oxidation-Reduction ; Oxygen ; Oxygen - analysis ; Oxygen - metabolism ; Prokaryotic Cells - metabolism ; Protein Structure, Tertiary ; Proteins ; Proteome - metabolism ; Science ; Science (multidisciplinary) ; Time Factors ; Topology</subject><ispartof>Nature (London), 2007-01, Vol.445 (7123), p.47-52</ispartof><rights>Springer Nature Limited 2006</rights><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 4, 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a599t-74d5315a87a9aa884115d9517b13b79185691c119e4c1a472a47fbf0e16795493</citedby><cites>FETCH-LOGICAL-a599t-74d5315a87a9aa884115d9517b13b79185691c119e4c1a472a47fbf0e16795493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nature05450$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nature05450$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18384846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17183269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kleffe, Jürgen</creatorcontrib><creatorcontrib>Acquisti, Claudia</creatorcontrib><creatorcontrib>Collins, Sinéad</creatorcontrib><title>Oxygen content of transmembrane proteins over macroevolutionary time scales</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>We observe that the time of appearance of cellular compartmentalization correlates with atmospheric oxygen concentration. To explore this correlation, we predict and characterize the topology of all transmembrane proteins in 19 taxa and correlate differences in topology with historical atmospheric oxygen concentrations. Here we show that transmembrane proteins, individually and as a group, were probably selectively excluding oxygen in ancient ancestral taxa, and that this constraint decreased over time when atmospheric oxygen levels rose. As this constraint decreased, the size and number of communication-related transmembrane proteins increased. We suggest the hypothesis that atmospheric oxygen concentrations affected the timing of the evolution of cellular compartmentalization by constraining the size of domains necessary for communication across membranes.
Coming up for air
Fossils are conventionally used to trace evolutionary change over time. But we may also preserve our history in our biochemistry. Claudia Acquisti
et al
. have discovered systematic variation in the ways in which various organisms incorporate oxygen into membrane-spanning proteins. Membrane proteins in compartmentalized prokaryotes and eukaryotes tend to contain more oxygen than those of simpler prokaryotes. This may be an echo of the low atmospheric oxygen on the early Earth.</description><subject>Animals</subject><subject>Atmosphere - chemistry</subject><subject>Atmospheric chemistry</subject><subject>Biological and medical sciences</subject><subject>Biological evolution</subject><subject>Cell Compartmentation - physiology</subject><subject>Cell Membrane - metabolism</subject><subject>Eukaryotic Cells - metabolism</subject><subject>Evolution, Molecular</subject><subject>Evolutionary biology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kleffe, Jürgen</au><au>Acquisti, Claudia</au><au>Collins, Sinéad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxygen content of transmembrane proteins over macroevolutionary time scales</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>2007-01-04</date><risdate>2007</risdate><volume>445</volume><issue>7123</issue><spage>47</spage><epage>52</epage><pages>47-52</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>We observe that the time of appearance of cellular compartmentalization correlates with atmospheric oxygen concentration. To explore this correlation, we predict and characterize the topology of all transmembrane proteins in 19 taxa and correlate differences in topology with historical atmospheric oxygen concentrations. Here we show that transmembrane proteins, individually and as a group, were probably selectively excluding oxygen in ancient ancestral taxa, and that this constraint decreased over time when atmospheric oxygen levels rose. As this constraint decreased, the size and number of communication-related transmembrane proteins increased. We suggest the hypothesis that atmospheric oxygen concentrations affected the timing of the evolution of cellular compartmentalization by constraining the size of domains necessary for communication across membranes.
Coming up for air
Fossils are conventionally used to trace evolutionary change over time. But we may also preserve our history in our biochemistry. Claudia Acquisti
et al
. have discovered systematic variation in the ways in which various organisms incorporate oxygen into membrane-spanning proteins. Membrane proteins in compartmentalized prokaryotes and eukaryotes tend to contain more oxygen than those of simpler prokaryotes. This may be an echo of the low atmospheric oxygen on the early Earth.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17183269</pmid><doi>10.1038/nature05450</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Animals Atmosphere - chemistry Atmospheric chemistry Biological and medical sciences Biological evolution Cell Compartmentation - physiology Cell Membrane - metabolism Eukaryotic Cells - metabolism Evolution, Molecular Evolutionary biology Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Humanities and Social Sciences Intracellular Membranes - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Models, Biological multidisciplinary Oxidation-Reduction Oxygen Oxygen - analysis Oxygen - metabolism Prokaryotic Cells - metabolism Protein Structure, Tertiary Proteins Proteome - metabolism Science Science (multidisciplinary) Time Factors Topology |
| title | Oxygen content of transmembrane proteins over macroevolutionary time scales |
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