Nucleotide Excision Repair and Homologous Recombination Systems Commit Differentially to the Repair of DNA-Protein Crosslinks

DNA-protein crosslinks (DPCs)—where proteins are covalently trapped on the DNA strand—block the progression of replication and transcription machineries and hence hamper the faithful transfer of genetic information. However, the repair mechanism of DPCs remains largely elusive. Here we have analyzed...

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Veröffentlicht in:	Molecular cell 2007-10, Vol.28 (1), p.147-158
Hauptverfasser:	Nakano, Toshiaki, Morishita, Soh, Katafuchi, Atsushi, Matsubara, Mayumi, Horikawa, Yusuke, Terato, Hiroaki, Salem, Amir M.H., Izumi, Shunsuke, Pack, Seung Pil, Makino, Keisuke, Ide, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azacitidine - metabolism Chromosomes - genetics Cross-Linking Reagents - metabolism DNA DNA - genetics DNA - metabolism DNA Damage DNA Helicases - genetics DNA Helicases - metabolism DNA Repair DNA Replication Endodeoxyribonucleases - metabolism Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Exodeoxyribonuclease V - genetics Exodeoxyribonuclease V - metabolism Formaldehyde - metabolism Humans Plasmids - genetics Plasmids - metabolism PROTEINS Recombination, Genetic
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