Biodistribution and Pharmacokinetic Analysis of Long-Circulating Thiolated Gelatin Nanoparticles Following Systemic Administration in Breast Cancer-Bearing Mice

The objective of the present study was to modify thiolated gelatin nanoparticles with poly(ethylene glycol) (PEG) chains and examine their long circulating and tumor-targeting properties in vivo in an orthotopic a human breast adenocarcinoma xenograft model. The crosslinked nanoparticle systems were...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2007-02, Vol.96 (2), p.397-407
Hauptverfasser:	Kommareddy, Sushma, Amiji, Mansoor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biodistribution Biological and medical sciences Breast Neoplasms - metabolism Cell Line, Tumor Chemistry, Pharmaceutical Female Gelatin - chemistry Gelatin - pharmacokinetics General pharmacology Humans Indium Radioisotopes long circulation time Medical sciences Mice Mice, Nude Microscopy, Electron, Scanning Nanoparticles - chemistry Nanoparticles - ultrastructure Neoplasm Transplantation Particle Size passive tumor targeting Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly(ethylene glycol) Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - pharmacokinetics surface modification Surface Properties thiolated gelatin nanoparticles Tissue Distribution
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