TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat

Viral infections are associated epidemiologically with the expression of type 1 diabetes in humans, but the mechanisms underlying this putative association are unknown. To investigate the role of viruses in diabetes, we used a model of viral induction of autoimmune diabetes in genetically susceptibl...

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Veröffentlicht in:	Journal of Immunology 2007-01, Vol.178 (2), p.693-701
Hauptverfasser:	Zipris, Danny, Lien, Egil, Nair, Anjali, Xie, Jenny X, Greiner, Dale L, Mordes, John P, Rossini, Aldo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism Breeding Cells, Cultured Chloroquine - pharmacology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - virology Disease Susceptibility DNA, Viral - genetics DNA, Viral - isolation & purification Female Genome, Viral - genetics Health Interleukin-12 Subunit p40 - biosynthesis Interleukin-12 Subunit p40 - metabolism Interleukin-6 - metabolism Kilham rat virus Macrophages - metabolism Male Membrane Proteins - immunology Membrane Proteins - metabolism NF-kappa B - metabolism Parvovirus Parvovirus - immunology Rats Signal Transduction Spleen - drug effects Spleen - immunology Spleen - metabolism Toll-Like Receptor 9 - deficiency Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Tumor Necrosis Factor-alpha - metabolism
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