Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects

Background In preclinical studies, lysolipid-based temperature-sensitive liposomes (LTSLs) containing chemotherapy drugs administered in combination with local hyperthermia have been found to increase tumor drug concentrations and improve antitumor efficacy of the drugs. We used a novel magnetic res...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2007-01, Vol.99 (1), p.53-63
Hauptverfasser:	Ponce, Ana M., Viglianti, Benjamin L., Yu, Daohai, Yarmolenko, Pavel S., Michelich, Charles R., Woo, Janet, Bally, Marcel B., Dewhirst, Mark W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics Antineoplastic agents Biological and medical sciences Cancer Chemotherapy Chromatography, High Pressure Liquid Contrast Media - administration & dosage Disease Models, Animal Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug delivery systems Drug dosages Female Fibrosarcoma - drug therapy Fibrosarcoma - metabolism Hyperthermia, Induced Liposomes Magnetic Resonance Imaging - methods Manganese Compounds - administration & dosage Medical imaging Medical sciences NMR Nuclear magnetic resonance Oncology Pharmacology Pharmacology. Drug treatments Rats Rats, Inbred F344 Time Factors Tumors
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