Collapsin response mediator protein‐2 hyperphosphorylation is an early event in Alzheimer’s disease progression

Collapsin response mediator protein 2 (CRMP2) is an abundant brain‐enriched protein that can regulate microtubule assembly in neurons. This function of CRMP2 is regulated by phosphorylation by glycogen synthase kinase 3 (GSK3) and cyclin‐dependent kinase 5 (Cdk5). Here, using novel phosphospecific a...

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Veröffentlicht in:	Journal of neurochemistry 2007-11, Vol.103 (3), p.1132-1144
Hauptverfasser:	Cole, Adam R., Noble, Wendy, Aalten, Lidy van, Plattner, Florian, Meimaridou, Rena, Hogan, Dale, Taylor, Margaret, LaFrancois, John, Gunn‐Moore, Frank, Verkhratsky, Alex, Oddo, Salvatore, LaFerla, Frank, Giese, K. Peter, Dineley, Kelly T., Duff, Karen, Richardson, Jill C., Yan, Shi Du, Hanger, Diane P., Allan, Stuart M., Sutherland, Calum
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aged Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Binding Sites Biochemistry Biological and medical sciences Brain - metabolism Brain - physiopathology collapsin response mediator protein 2 Cyclin-Dependent Kinase 5 - metabolism cyclin‐dependent kinase 5 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Disease Progression Gene Expression Regulation - physiology glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - metabolism Humans Intercellular Signaling Peptides and Proteins - metabolism Medical sciences Mice Mice, Transgenic Microtubules - metabolism Nerve Tissue Proteins - metabolism Neurofibrillary Tangles - metabolism Neurology Neurons - metabolism Organic mental disorders. Neuropsychology Phosphorylation Plaque, Amyloid - metabolism Proteins Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rodents Time Factors Transgenic animals
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