Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs

Abstract In this study, a block copolymer, poly( N -isopropylacrylamide- co - N , N -dimethylacrylamide- co -2-aminoethyl methacrylate)- b -poly(10-undecenoic acid) (P(NIPAAm- co -DMAAm- co -AMA)- b -PUA) was synthesized, and folic acid was conjugated to the hydrophilic block through the amine group...

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Veröffentlicht in:	Biomaterials 2007-03, Vol.28 (7), p.1423-1433
Hauptverfasser:	Liu, Shao-Qiong, Wiradharma, Nikken, Gao, Shu-Jun, Tong, Yen Wah, Yang, Yi-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biodistribution Block copolymer Cell Line, Tumor Dentistry Doxorubicin Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug Delivery Systems Drug Implants Female Folic Acid - analogs & derivatives Folic Acid - chemistry Humans Hydrogen-Ion Concentration Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Materials Testing Mice Mice, Inbred BALB C Micelles Particle Size pH- and temperature-sensitive Polymers - chemical synthesis Polymers - chemistry
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