Molecular impact of clenbuterol and isometric strength training on rat EDL muscles

Clenbuterol, a beta2-adrenergic-receptor agonist, is known to provoke muscle hypertrophy and a slow-to-fast phenotype change. A more glycolytic phenotype should be paralleled by changes in muscle glycolytic metabolism. Two groups (n=16 for each) of 3-month-old male Wistar rats (UCL: untrained clenbu...

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Veröffentlicht in:	Pflügers Archiv 2007-01, Vol.453 (4), p.497-507
Hauptverfasser:	Mounier, Rémi, Cavalié, Hélian, Lac, Gérard, Clottes, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - administration & dosage Adrenergic beta-Agonists - pharmacology Animals Body Weight - drug effects Citrate (si)-Synthase - genetics Citrate (si)-Synthase - metabolism Clenbuterol - administration & dosage Clenbuterol - pharmacology Creatine Kinase - genetics Creatine Kinase - metabolism Gene Expression - drug effects Genotype & phenotype Glucose Transporter Type 1 - genetics Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - metabolism Glycolysis - drug effects Hexokinase - metabolism Insulin-Like Growth Factor I - metabolism Isometric Contraction - drug effects Male Monocarboxylic Acid Transporters - genetics Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Muscular system Myosin Heavy Chains - metabolism Physical Conditioning, Animal - physiology Protein Isoforms - metabolism Rats Rats, Wistar Receptor, IGF Type 1 - blood Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Sports training Symporters - genetics
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