Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells

Myeloid dendritic cells (mDCs) recognize and respond to polyI:C, an analog of dsRNA, by endosomal Toll-like receptor (TLR) 3 and cytoplasmic receptors. Natural killer (NK) cells are activated in vivo by the administration of polyI:C to mice and in vivo are reciprocally activated by mDCs, although th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-01, Vol.104 (1), p.252-257
Hauptverfasser:	Akazawa, Takashi, Ebihara, Takashi, Okuno, Manabu, Okuda, Yu, Shingai, Masashi, Tsujimura, Kunio, Takahashi, Toshitada, Ikawa, Masahito, Okabe, Masaru, Inoue, Norimitsu, Okamoto-Tanaka, Miki, Ishizaki, Hiroyoshi, Miyoshi, Jun, Matsumoto, Misako, Seya, Tsukasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - physiology Animals Biological Sciences Cellular biology Complementary DNA Cytokines Cytotoxicity Dendritic cells Dendritic Cells - immunology Double stranded RNA Genes Genetic vectors Immunity (Disease) Killer Cells, Natural - immunology Lymphocyte Activation Melanoma, Experimental - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Myeloid Cells - immunology Natural killer cells Poly I-C - pharmacology Receptor, Interferon alpha-beta - physiology Rodents Toll like receptors Toll-Like Receptor 3 - physiology Tumor burden Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!