Suppression of Skin Lesions by Transdermal Application of CpG-Oligodeoxynucleotides in NC/Nga Mice, a Model of Human Atopic Dermatitis

Atopic dermatitis (AD) is a pruritic inflammatory skin disease characterized by an elevation of the total IgE level in plasma, the infiltration of mast cells and eosinophils, and the expression of cytokines by Th2 cells. NC/Nga mice kept in conventional conditions are known to develop skin lesions r...

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Veröffentlicht in:	Journal of Immunology 2007-01, Vol.178 (1), p.584-591
Hauptverfasser:	Inoue, Joe, Aramaki, Yukihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Antibodies - blood Cytokines - genetics Cytokines - metabolism Dermatitis, Atopic - drug therapy Dermatitis, Atopic - pathology Humans Immunoglobulin E - blood Immunosuppression Mast Cells Mice Mice, Inbred Strains Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - analysis Oligodeoxyribonucleotides - therapeutic use Pruritus - drug therapy RNA, Messenger - analysis RNA, Messenger - metabolism Skin - drug effects Skin - immunology Skin - pathology Th2 Cells - drug effects Th2 Cells - immunology
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