Isoliquiritigenin, One of the Antispasmodic Principles of Glycyrrhiza Ularensis Roots, Acts in the Lower Part of Intestine

Glycyrrhizae Radix is used to treat abdominal pain as a component of Shakuyakukanzoto (Shaoyao-Gancao-tang), a traditional Chinese medicine formulation. Previously, we have reported the isolation of glycycoumarin as a potent antispasmodic with an IC50 value of 2.93±0.94 μM for carbamylcholine (CCh)-...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2007, Vol.30(1), pp.145-149
Hauptverfasser:	Sato, Yuji, He, Ju-Xiu, Nagai, Hidemasa, Tani, Tadato, Akao, Teruaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antispasmodic beta-Glucosidase - metabolism Chalcones - isolation & purification Chalcones - metabolism Chalcones - pharmacology davidigenin Dose-Response Relationship, Drug Glycoside Hydrolases - metabolism Glycyrrhiza uralensis Glycyrrhiza uralensis - chemistry Ileum - drug effects In Vitro Techniques Intestines - drug effects isoliquiritigenin Jejunum - drug effects Male Mice Mice, Inbred ICR Multienzyme Complexes - metabolism Muscle Contraction - drug effects Muscle, Smooth - drug effects naringinase Papaverine - pharmacology Parasympatholytics - isolation & purification Parasympatholytics - metabolism Parasympatholytics - pharmacology Phosphodiesterase Inhibitors - pharmacology Plant Extracts - pharmacology Plant Roots Rectum - drug effects Shakuyakukanzoto
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