Resolution of Holliday Junction Substrates by Human Topoisomerase I

Prompted by the close relationship between tyrosine recombinases and type IB topoisomerases we have investigated the ability of human topoisomerase I to resolve the typical intermediate of recombinase catalysis, the Holliday junction. We demonstrate that human topoisomerase I catalyzes unidirectiona...

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Veröffentlicht in:	Journal of molecular biology 2007-01, Vol.365 (4), p.1076-1092
Hauptverfasser:	Hede, Marianne S., Petersen, Rikke L., Frøhlich, Rikke F., Krüger, Dinna, Andersen, Felicie F., Andersen, Anni H., Knudsen, Birgitta R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites camptothecin Camptothecin - chemistry Catalysis Cross-Linking Reagents - chemistry Cross-Linking Reagents - pharmacology Dimerization DNA - chemistry DNA Topoisomerases, Type I - chemistry DNA, Cruciform - chemistry genomic stability Holliday junction Humans Molecular Sequence Data Oligonucleotides - chemistry Protein Conformation Protein Structure, Tertiary recombination Substrate Specificity topoisomerase I
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