Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX-2 Expression in Human Monocytic Cells

Tetrandrine (TET), a bis-benzylisoquinoline alkaloid isolated from the dried root of Hang-Fang-Chi (Stephania tetrandra S. MOORE), is traditionally used in China for treating inflammation, hypertension and silicosis. In this study, our aim was to examine the anti-inflammatory mechanism of TET throug...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2007, Vol.30(1), pp.59-62
Hauptverfasser:	Wu, Shu-Jing, Ng, Lean-Teik
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Anti-Inflammatory Agents - pharmacology Benzylisoquinolines - pharmacology Cell Line Cell Survival - drug effects COX-2 Cyclooxygenase 1 - biosynthesis Cyclooxygenase 2 - biosynthesis cytokine Cytokines - biosynthesis Dinoprostone - metabolism Gene Expression Regulation - drug effects Humans inducible nitric oxide synthase (iNOS) Interleukin-4 - biosynthesis Interleukin-8 - biosynthesis Interleukin-8 - metabolism Lipopolysaccharides - pharmacology Membrane Proteins - biosynthesis Monocytes - drug effects Monocytes - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type II - biosynthesis tetrandrine THP-1 cell Tumor Necrosis Factor-alpha - biosynthesis
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