Synthesis and biological activity of homoarginine-containing opioid peptides

Two tris‐alkoxycarbonyl homoarginine derivatives, Boc‐Har{ω,ω′‐[Z(2Br)]2}‐OH and Boc‐Har{ω,ω′‐[Z(2Cl)]2}‐OH, were prepared by guanidinylation of Boc‐Lys‐OH, and used for the synthesis of neo‐endorphins and dynorphins. The results were compared with that obtained in the synthesis in which Boc‐Lys(Fmo...

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