Expression of Cellular FLICE Inhibitory Protein, Caspase-8, and Protease Inhibitor-9 in Ewing Sarcoma and Implications for Susceptibility to Cytotoxic Pathways

Purpose: Ewing sarcoma is a common pediatric bone tumor with an unfavorable prognosis for metastatic or recurrent disease. Cellular immunotherapy may provide new treatment options and depends on the cytolytic death receptor and perforin/granzyme pathways. Expression of death receptor pathway inhibit...

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Veröffentlicht in:	Clinical cancer research 2007-01, Vol.13 (1), p.206-214
Hauptverfasser:	DE HOOGE, Alfons S. K, BERGHUIS, Dagmar, LANKESTER, Arjan C, SANTOS, Susyjusto, MOOIMAN, Esther, ROMEO, Salvatore, ALAIN KUMMER, J, MAARTEN EGELER, R, VAN TOL, Maarten J. D, MELIEF, Cornelis J. M, HOGENDOORN, Pancras C. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiapoptotic proteins Antineoplastic agents Apoptosis Biological and medical sciences Biomarkers, Tumor Biopsy Bone tumor CASP8 and FADD-Like Apoptosis Regulating Protein - biosynthesis Caspase 8 - biosynthesis Caspase 8 - metabolism caspase-8 Caspases Cell Line, Tumor cellular immunotherapy Diseases of the osteoarticular system DNA Fragmentation Ewing sarcoma fas Receptor - biosynthesis Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Immunohistochemistry Immunotherapy - methods Medical sciences Pediatric cancers Pharmacology. Drug treatments Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Serpins - biosynthesis Tumor resistance to immune response Tumors of striated muscle and skeleton
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