Platelet Factor 4 (CXCL4) Seals Blood Clots by Altering the Structure of Fibrin

Platelet factor-4 (PF4/CXCL4) is an orphan chemokine released in large quantities in the vicinity of growing blood clots. Coagulation of plasma supplemented with a matching amount of PF4 results in a translucent jelly-like clot. Saturating amounts of PF4 reduce the porosity of the fibrin network 4.4...

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Veröffentlicht in:	The Journal of biological chemistry 2007-01, Vol.282 (1), p.710-720
Hauptverfasser:	Amelot, Aymeric A., Tagzirt, Madjid, Ducouret, Guylaine, Kuen, René Lai, Le Bonniec, Bernard F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation Cross-Linking Reagents - pharmacology Dimerization Fibrin - chemistry Fibrinogen - chemistry Gamma Rays Humans Kinetics Marine Microscopy, Electron, Scanning Models, Molecular Peptides - chemistry Phocidae Platelet Factor 4 - chemistry Platelet Factor 4 - physiology Polymers - chemistry Protein Binding Static Electricity
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