Inactivation of Signal Transducer and Activator of Transcription 3 in Proopiomelanocortin (Pomc) Neurons Causes Decreased Pomc Expression, Mild Obesity, and Defects in Compensatory Refeeding

Leptin is an adipocyte-derived hormone that signals body energy status to the brain by acting on multiple neuronal subgroups in the hypothalamus, including those that express proopiomelanocortin (Pomc) and agouti-related protein (Agrp). Signal transducer and activator of transcription 3 (Stat3) is a...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2007-01, Vol.148 (1), p.72-80
Hauptverfasser:	Xu, Allison W, Ste-Marie, Linda, Kaelin, Christopher B, Barsh, Gregory S
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti-related protein Animals Biological and medical sciences Body weight Cre recombinase Dietary Fats - pharmacology Energy balance Energy Metabolism - physiology Feeding Behavior - physiology Female Fundamental and applied biological sciences. Psychology Gene regulation High fat diet Homeostasis - physiology Hypophagia Hypothalamus Inactivation Intracellular signalling Leptin - metabolism Leptin - pharmacology Male Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Mice, Knockout Mutants Neurons Obesity Obesity - metabolism Obesity - physiopathology Phosphorylation Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Proopiomelanocortin RNA, Messenger - metabolism Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Subgroups Transcription, Genetic - physiology Transducers Transgenes Vertebrates: endocrinology Weight Gain - physiology
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