Recent Advances in Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) consists of a combination of obesity and chronic hypercapnia accompanied by sleep-disordered breathing. During the last 3 decades, the prevalence of extreme obesity has markedly increased in the United States and other countries. With a global epidemic of obesi...
Gespeichert in:
| Veröffentlicht in: | Chest 2007-10, Vol.132 (4), p.1322-1336 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1336 |
|---|---|
| container_issue | 4 |
| container_start_page | 1322 |
| container_title | Chest |
| container_volume | 132 |
| creator | Mokhlesi, Babak Tulaimat, Aiman |
| description | Obesity hypoventilation syndrome (OHS) consists of a combination of obesity and chronic hypercapnia accompanied by sleep-disordered breathing. During the last 3 decades, the prevalence of extreme obesity has markedly increased in the United States and other countries. With a global epidemic of obesity, the prevalence of OHS is bound to increase. Patients with OHS have a lower quality of life with increased health-care expenses and are at a higher risk for the development of pulmonary hypertension and early mortality compared to eucapnic patients with sleep-disordered breathing. Despite the significant morbidity and mortality associated with this syndrome, it is often unrecognized and treatment is frequently delayed. Clinicians must maintain a high index of suspicion since early recognition and treatment reduces the high burden of morbidity and mortality associated with this syndrome. In this review, we will discuss the definition and clinical presentation of OHS, provide a summary of its prevalence, review the current understanding of the pathophysiology, and discuss the recent advances in the therapeutic options. |
| doi_str_mv | 10.1378/chest.07-0027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68382671</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0012369215367301</els_id><sourcerecordid>68382671</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-83d407e7e519478715ce0cb7ed0b71edca7c9ab5186157cf436b1fdcc31cb8d3</originalsourceid><addsrcrecordid>eNp1kEtLxDAURoMoOj6WbqUb3VVzm7ZJlyK-QBDUfUhvbp0MfYxJZ2T-vdEOzMpVCDnfl3sPY-fAr0FIdYNzCuM1lynnmdxjM6gEpKLIxT6bcQ5ZKsoqO2LHISx4vENVHrIjkJXIAdSMiTdC6sfk1q5NjxQS1yevNQU3bpKnzXJYx0fXmtENffK-6a0fOjplB41pA51tzxP28XD_cfeUvrw-Pt_dvqSYAx9TJWzOJUkqoMqlklAgcawlWV5LIItGYmXqAlQJhcQmF2UNjUUUgLWy4oRdTbVLP3yt4pa6cwGpbU1PwyroUgmVlRIimE4g-iEET41eetcZv9HA9a8k_SdJc6l_JUX-Ylu8qjuyO3prJQKXW8AENG3joxoXdlwFqiqzMnJ84ubuc_7tPOnQmbaNtWL6cjGsfG9aEJnO4yRZFiNyilAUt3bkdUBH0byNcRy1Hdw_U_8AKV-UTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68382671</pqid></control><display><type>article</type><title>Recent Advances in Obesity Hypoventilation Syndrome</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Mokhlesi, Babak ; Tulaimat, Aiman</creator><creatorcontrib>Mokhlesi, Babak ; Tulaimat, Aiman</creatorcontrib><description>Obesity hypoventilation syndrome (OHS) consists of a combination of obesity and chronic hypercapnia accompanied by sleep-disordered breathing. During the last 3 decades, the prevalence of extreme obesity has markedly increased in the United States and other countries. With a global epidemic of obesity, the prevalence of OHS is bound to increase. Patients with OHS have a lower quality of life with increased health-care expenses and are at a higher risk for the development of pulmonary hypertension and early mortality compared to eucapnic patients with sleep-disordered breathing. Despite the significant morbidity and mortality associated with this syndrome, it is often unrecognized and treatment is frequently delayed. Clinicians must maintain a high index of suspicion since early recognition and treatment reduces the high burden of morbidity and mortality associated with this syndrome. In this review, we will discuss the definition and clinical presentation of OHS, provide a summary of its prevalence, review the current understanding of the pathophysiology, and discuss the recent advances in the therapeutic options.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.07-0027</identifier><identifier>PMID: 17934118</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Acetazolamide - therapeutic use ; Algorithms ; Animals ; Bariatric Surgery ; bilevel positive airway pressure ; Biological and medical sciences ; Cardiology. Vascular system ; Comorbidity ; Continuous Positive Airway Pressure ; Contraceptives, Oral, Synthetic - therapeutic use ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Diuretics - therapeutic use ; Humans ; hypercapnia ; Hypercapnia - etiology ; Hypercapnia - therapy ; hypoventilation ; Leptin - physiology ; Medical sciences ; Medroxyprogesterone - therapeutic use ; Metabolic diseases ; Nervous system (semeiology, syndromes) ; Neurology ; Obesity ; obesity hypoventilation syndrome ; Obesity Hypoventilation Syndrome - diagnosis ; Obesity Hypoventilation Syndrome - epidemiology ; Obesity Hypoventilation Syndrome - physiopathology ; Obesity Hypoventilation Syndrome - therapy ; pickwickian syndrome ; Pneumology ; Positive-Pressure Respiration ; Quality of Life ; Respiratory Muscles - physiopathology ; Respiratory system : syndromes and miscellaneous diseases ; sleep apnea ; sleep-disordered breathing ; Tracheostomy ; Treatment Outcome</subject><ispartof>Chest, 2007-10, Vol.132 (4), p.1322-1336</ispartof><rights>2007 The American College of Chest Physicians</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-83d407e7e519478715ce0cb7ed0b71edca7c9ab5186157cf436b1fdcc31cb8d3</citedby><cites>FETCH-LOGICAL-c410t-83d407e7e519478715ce0cb7ed0b71edca7c9ab5186157cf436b1fdcc31cb8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19189626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17934118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mokhlesi, Babak</creatorcontrib><creatorcontrib>Tulaimat, Aiman</creatorcontrib><title>Recent Advances in Obesity Hypoventilation Syndrome</title><title>Chest</title><addtitle>Chest</addtitle><description>Obesity hypoventilation syndrome (OHS) consists of a combination of obesity and chronic hypercapnia accompanied by sleep-disordered breathing. During the last 3 decades, the prevalence of extreme obesity has markedly increased in the United States and other countries. With a global epidemic of obesity, the prevalence of OHS is bound to increase. Patients with OHS have a lower quality of life with increased health-care expenses and are at a higher risk for the development of pulmonary hypertension and early mortality compared to eucapnic patients with sleep-disordered breathing. Despite the significant morbidity and mortality associated with this syndrome, it is often unrecognized and treatment is frequently delayed. Clinicians must maintain a high index of suspicion since early recognition and treatment reduces the high burden of morbidity and mortality associated with this syndrome. In this review, we will discuss the definition and clinical presentation of OHS, provide a summary of its prevalence, review the current understanding of the pathophysiology, and discuss the recent advances in the therapeutic options.</description><subject>Acetazolamide - therapeutic use</subject><subject>Algorithms</subject><subject>Animals</subject><subject>Bariatric Surgery</subject><subject>bilevel positive airway pressure</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Comorbidity</subject><subject>Continuous Positive Airway Pressure</subject><subject>Contraceptives, Oral, Synthetic - therapeutic use</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Diuretics - therapeutic use</subject><subject>Humans</subject><subject>hypercapnia</subject><subject>Hypercapnia - etiology</subject><subject>Hypercapnia - therapy</subject><subject>hypoventilation</subject><subject>Leptin - physiology</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone - therapeutic use</subject><subject>Metabolic diseases</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Obesity</subject><subject>obesity hypoventilation syndrome</subject><subject>Obesity Hypoventilation Syndrome - diagnosis</subject><subject>Obesity Hypoventilation Syndrome - epidemiology</subject><subject>Obesity Hypoventilation Syndrome - physiopathology</subject><subject>Obesity Hypoventilation Syndrome - therapy</subject><subject>pickwickian syndrome</subject><subject>Pneumology</subject><subject>Positive-Pressure Respiration</subject><subject>Quality of Life</subject><subject>Respiratory Muscles - physiopathology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>sleep apnea</subject><subject>sleep-disordered breathing</subject><subject>Tracheostomy</subject><subject>Treatment Outcome</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAURoMoOj6WbqUb3VVzm7ZJlyK-QBDUfUhvbp0MfYxJZ2T-vdEOzMpVCDnfl3sPY-fAr0FIdYNzCuM1lynnmdxjM6gEpKLIxT6bcQ5ZKsoqO2LHISx4vENVHrIjkJXIAdSMiTdC6sfk1q5NjxQS1yevNQU3bpKnzXJYx0fXmtENffK-6a0fOjplB41pA51tzxP28XD_cfeUvrw-Pt_dvqSYAx9TJWzOJUkqoMqlklAgcawlWV5LIItGYmXqAlQJhcQmF2UNjUUUgLWy4oRdTbVLP3yt4pa6cwGpbU1PwyroUgmVlRIimE4g-iEET41eetcZv9HA9a8k_SdJc6l_JUX-Ylu8qjuyO3prJQKXW8AENG3joxoXdlwFqiqzMnJ84ubuc_7tPOnQmbaNtWL6cjGsfG9aEJnO4yRZFiNyilAUt3bkdUBH0byNcRy1Hdw_U_8AKV-UTQ</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Mokhlesi, Babak</creator><creator>Tulaimat, Aiman</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Recent Advances in Obesity Hypoventilation Syndrome</title><author>Mokhlesi, Babak ; Tulaimat, Aiman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-83d407e7e519478715ce0cb7ed0b71edca7c9ab5186157cf436b1fdcc31cb8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acetazolamide - therapeutic use</topic><topic>Algorithms</topic><topic>Animals</topic><topic>Bariatric Surgery</topic><topic>bilevel positive airway pressure</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Comorbidity</topic><topic>Continuous Positive Airway Pressure</topic><topic>Contraceptives, Oral, Synthetic - therapeutic use</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Diuretics - therapeutic use</topic><topic>Humans</topic><topic>hypercapnia</topic><topic>Hypercapnia - etiology</topic><topic>Hypercapnia - therapy</topic><topic>hypoventilation</topic><topic>Leptin - physiology</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone - therapeutic use</topic><topic>Metabolic diseases</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Obesity</topic><topic>obesity hypoventilation syndrome</topic><topic>Obesity Hypoventilation Syndrome - diagnosis</topic><topic>Obesity Hypoventilation Syndrome - epidemiology</topic><topic>Obesity Hypoventilation Syndrome - physiopathology</topic><topic>Obesity Hypoventilation Syndrome - therapy</topic><topic>pickwickian syndrome</topic><topic>Pneumology</topic><topic>Positive-Pressure Respiration</topic><topic>Quality of Life</topic><topic>Respiratory Muscles - physiopathology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>sleep apnea</topic><topic>sleep-disordered breathing</topic><topic>Tracheostomy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mokhlesi, Babak</creatorcontrib><creatorcontrib>Tulaimat, Aiman</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mokhlesi, Babak</au><au>Tulaimat, Aiman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent Advances in Obesity Hypoventilation Syndrome</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>132</volume><issue>4</issue><spage>1322</spage><epage>1336</epage><pages>1322-1336</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Obesity hypoventilation syndrome (OHS) consists of a combination of obesity and chronic hypercapnia accompanied by sleep-disordered breathing. During the last 3 decades, the prevalence of extreme obesity has markedly increased in the United States and other countries. With a global epidemic of obesity, the prevalence of OHS is bound to increase. Patients with OHS have a lower quality of life with increased health-care expenses and are at a higher risk for the development of pulmonary hypertension and early mortality compared to eucapnic patients with sleep-disordered breathing. Despite the significant morbidity and mortality associated with this syndrome, it is often unrecognized and treatment is frequently delayed. Clinicians must maintain a high index of suspicion since early recognition and treatment reduces the high burden of morbidity and mortality associated with this syndrome. In this review, we will discuss the definition and clinical presentation of OHS, provide a summary of its prevalence, review the current understanding of the pathophysiology, and discuss the recent advances in the therapeutic options.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>17934118</pmid><doi>10.1378/chest.07-0027</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 2007-10, Vol.132 (4), p.1322-1336 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68382671 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acetazolamide - therapeutic use Algorithms Animals Bariatric Surgery bilevel positive airway pressure Biological and medical sciences Cardiology. Vascular system Comorbidity Continuous Positive Airway Pressure Contraceptives, Oral, Synthetic - therapeutic use Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Diuretics - therapeutic use Humans hypercapnia Hypercapnia - etiology Hypercapnia - therapy hypoventilation Leptin - physiology Medical sciences Medroxyprogesterone - therapeutic use Metabolic diseases Nervous system (semeiology, syndromes) Neurology Obesity obesity hypoventilation syndrome Obesity Hypoventilation Syndrome - diagnosis Obesity Hypoventilation Syndrome - epidemiology Obesity Hypoventilation Syndrome - physiopathology Obesity Hypoventilation Syndrome - therapy pickwickian syndrome Pneumology Positive-Pressure Respiration Quality of Life Respiratory Muscles - physiopathology Respiratory system : syndromes and miscellaneous diseases sleep apnea sleep-disordered breathing Tracheostomy Treatment Outcome |
| title | Recent Advances in Obesity Hypoventilation Syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T12%3A25%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recent%20Advances%20in%20Obesity%20Hypoventilation%20Syndrome&rft.jtitle=Chest&rft.au=Mokhlesi,%20Babak&rft.date=2007-10-01&rft.volume=132&rft.issue=4&rft.spage=1322&rft.epage=1336&rft.pages=1322-1336&rft.issn=0012-3692&rft.eissn=1931-3543&rft.coden=CHETBF&rft_id=info:doi/10.1378/chest.07-0027&rft_dat=%3Cproquest_cross%3E68382671%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68382671&rft_id=info:pmid/17934118&rft_els_id=S0012369215367301&rfr_iscdi=true |