Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits
Abstract Intake of Concord grape juice (CGJ), rich in polyphenolics, inhibits platelet aggregation (PA), a risk factor for cardiovascular disease (CVD), in normocholesterolemic animals and humans. It is unclear whether CGJ can attenuate hypercholesterolemia-enhanced PA. The effects of daily CGJ cons...
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| Veröffentlicht in: | Atherosclerosis 2007-01, Vol.190 (1), p.135-142 |
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| creator | Shanmuganayagam, Dhanansayan Warner, Thomas F Krueger, Christian G Reed, Jess D Folts, John D |
| description | Abstract Intake of Concord grape juice (CGJ), rich in polyphenolics, inhibits platelet aggregation (PA), a risk factor for cardiovascular disease (CVD), in normocholesterolemic animals and humans. It is unclear whether CGJ can attenuate hypercholesterolemia-enhanced PA. The effects of daily CGJ consumption on hypercholesterolemia-enhanced PA and the development of atherosclerosis were investigated. Two groups of rabbits (Control and Treated; n = 10 each) were fed a hypercholesterolemic diet for 48 days. Treated group then received supplemental CGJ (225 mL/day) while Control group received supplemental iso-caloric sugar water for 48 days. Collagen-, collagen + epinephrine- and phorbol-12-myristate-13-acetate-induced whole blood PA responses were measured on Days 0, 48 and 96; total serum cholesterol and blood pressure were also measured. The development of aortic atheroma was quantified at the end. Both groups showed significant increases in PA and serum cholesterol at Day 48. However, at Day 96, Treated group showed significantly lower PA and development of atheroma (30.7 ± 3.9% lower ( p < 0.001)) than Control group; Treated group also had significantly lower total serum cholesterol and blood pressure than Control group. In conclusion, daily consumption of CGJ attenuates hypercholesterolemia-enhanced PA, blood pressure, total serum cholesterol and development of atheroma in rabbits. |
| doi_str_mv | 10.1016/j.atherosclerosis.2006.03.017 |
| format | Article |
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It is unclear whether CGJ can attenuate hypercholesterolemia-enhanced PA. The effects of daily CGJ consumption on hypercholesterolemia-enhanced PA and the development of atherosclerosis were investigated. Two groups of rabbits (Control and Treated; n = 10 each) were fed a hypercholesterolemic diet for 48 days. Treated group then received supplemental CGJ (225 mL/day) while Control group received supplemental iso-caloric sugar water for 48 days. Collagen-, collagen + epinephrine- and phorbol-12-myristate-13-acetate-induced whole blood PA responses were measured on Days 0, 48 and 96; total serum cholesterol and blood pressure were also measured. The development of aortic atheroma was quantified at the end. Both groups showed significant increases in PA and serum cholesterol at Day 48. However, at Day 96, Treated group showed significantly lower PA and development of atheroma (30.7 ± 3.9% lower ( p < 0.001)) than Control group; Treated group also had significantly lower total serum cholesterol and blood pressure than Control group. In conclusion, daily consumption of CGJ attenuates hypercholesterolemia-enhanced PA, blood pressure, total serum cholesterol and development of atheroma in rabbits.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2006.03.017</identifier><identifier>PMID: 16780846</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Animals ; Aorta - pathology ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - drug therapy ; Atherosclerosis - pathology ; Atherosclerosis - prevention & control ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood coagulation. Blood cells ; Blood Pressure - drug effects ; Blood vessels and receptors ; Body Weight - drug effects ; Cardiology. Vascular system ; Cardiovascular ; Cholesterol ; Cholesterol - blood ; Flavonoids - pharmacology ; Fundamental and applied biological sciences. Psychology ; Grape juice ; Hypercholesterolemia ; Hypercholesterolemia - drug therapy ; Hypercholesterolemia - pathology ; Male ; Medical sciences ; Molecular and cellular biology ; Phenols - pharmacology ; Phytotherapy ; Platelet ; Platelet Aggregation - drug effects ; Platelets ; Polyphenolics ; Polyphenols ; Rabbits ; Vertebrates: cardiovascular system ; Vitis</subject><ispartof>Atherosclerosis, 2007-01, Vol.190 (1), p.135-142</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2006 Elsevier Ireland Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-c41982895bc502e255f41f99ad7fbed84feb840da6f1528a976c62fc3f62a9b03</citedby><cites>FETCH-LOGICAL-c538t-c41982895bc502e255f41f99ad7fbed84feb840da6f1528a976c62fc3f62a9b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2006.03.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18445482$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16780846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shanmuganayagam, Dhanansayan</creatorcontrib><creatorcontrib>Warner, Thomas F</creatorcontrib><creatorcontrib>Krueger, Christian G</creatorcontrib><creatorcontrib>Reed, Jess D</creatorcontrib><creatorcontrib>Folts, John D</creatorcontrib><title>Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Intake of Concord grape juice (CGJ), rich in polyphenolics, inhibits platelet aggregation (PA), a risk factor for cardiovascular disease (CVD), in normocholesterolemic animals and humans. It is unclear whether CGJ can attenuate hypercholesterolemia-enhanced PA. The effects of daily CGJ consumption on hypercholesterolemia-enhanced PA and the development of atherosclerosis were investigated. Two groups of rabbits (Control and Treated; n = 10 each) were fed a hypercholesterolemic diet for 48 days. Treated group then received supplemental CGJ (225 mL/day) while Control group received supplemental iso-caloric sugar water for 48 days. Collagen-, collagen + epinephrine- and phorbol-12-myristate-13-acetate-induced whole blood PA responses were measured on Days 0, 48 and 96; total serum cholesterol and blood pressure were also measured. The development of aortic atheroma was quantified at the end. Both groups showed significant increases in PA and serum cholesterol at Day 48. However, at Day 96, Treated group showed significantly lower PA and development of atheroma (30.7 ± 3.9% lower ( p < 0.001)) than Control group; Treated group also had significantly lower total serum cholesterol and blood pressure than Control group. In conclusion, daily consumption of CGJ attenuates hypercholesterolemia-enhanced PA, blood pressure, total serum cholesterol and development of atheroma in rabbits.</description><subject>Animals</subject><subject>Aorta - pathology</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - drug therapy</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerosis - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Pressure - drug effects</subject><subject>Blood vessels and receptors</subject><subject>Body Weight - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Flavonoids - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Grape juice</subject><subject>Hypercholesterolemia</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Hypercholesterolemia - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>Phenols - pharmacology</subject><subject>Phytotherapy</subject><subject>Platelet</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelets</subject><subject>Polyphenolics</subject><subject>Polyphenols</subject><subject>Rabbits</subject><subject>Vertebrates: cardiovascular system</subject><subject>Vitis</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkGP0zAQhSMEYsvCX0C-LCdaxonjOAeQUAUL0kocgLPlOOPWxbGD7azUK78cV60A7YnLzOWbmaf3pqpuKGwoUP7msFF5jzEk7U7Vpk0NwDfQbIB2j6oVFV2_pkywx9UKoKbrnrZwVT1L6QAArKPiaXVFeSdAML6qfm2D1yGOZBfVjOSwWI1E5Yx-URkTmV1pDjNRu13Enco2-NckYVwmovfBYcpFhiPKj2TEe3RhntBnEgw565wUsZ7sjzPGf3icrCZRDYPN6Xn1xCiX8MWlX1ffP374tv20vvty-3n7_m6t20bktWa0F7Xo20G3UGPdtoZR0_dq7MyAo2AGB8FgVNzQthaq77jmtdGN4bXqB2iuq1fnvXMMP5ciRE42aXROeQxLklw0gnLaFPDtGdTF4BTRyDnaScWjpCBPIciDfBCCPIUgoZElhDL_8nJoGSYc_05fXC_AzQVQSStnovK67PjDCcZaJurC3Z45LLbcW4wyaYte42gj6izHYP9b0rsHm7Sz3pbjP_CI6RCW6Iv3kspUS5BfT59zehzgALQB1vwGImnIOA</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Shanmuganayagam, Dhanansayan</creator><creator>Warner, Thomas F</creator><creator>Krueger, Christian G</creator><creator>Reed, Jess D</creator><creator>Folts, John D</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits</title><author>Shanmuganayagam, Dhanansayan ; Warner, Thomas F ; Krueger, Christian G ; Reed, Jess D ; Folts, John D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-c41982895bc502e255f41f99ad7fbed84feb840da6f1528a976c62fc3f62a9b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Aorta - pathology</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - drug therapy</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerosis - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Pressure - drug effects</topic><topic>Blood vessels and receptors</topic><topic>Body Weight - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Flavonoids - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Grape juice</topic><topic>Hypercholesterolemia</topic><topic>Hypercholesterolemia - drug therapy</topic><topic>Hypercholesterolemia - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>Phenols - pharmacology</topic><topic>Phytotherapy</topic><topic>Platelet</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelets</topic><topic>Polyphenolics</topic><topic>Polyphenols</topic><topic>Rabbits</topic><topic>Vertebrates: cardiovascular system</topic><topic>Vitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shanmuganayagam, Dhanansayan</creatorcontrib><creatorcontrib>Warner, Thomas F</creatorcontrib><creatorcontrib>Krueger, Christian G</creatorcontrib><creatorcontrib>Reed, Jess D</creatorcontrib><creatorcontrib>Folts, John D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shanmuganayagam, Dhanansayan</au><au>Warner, Thomas F</au><au>Krueger, Christian G</au><au>Reed, Jess D</au><au>Folts, John D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>190</volume><issue>1</issue><spage>135</spage><epage>142</epage><pages>135-142</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Intake of Concord grape juice (CGJ), rich in polyphenolics, inhibits platelet aggregation (PA), a risk factor for cardiovascular disease (CVD), in normocholesterolemic animals and humans. It is unclear whether CGJ can attenuate hypercholesterolemia-enhanced PA. The effects of daily CGJ consumption on hypercholesterolemia-enhanced PA and the development of atherosclerosis were investigated. Two groups of rabbits (Control and Treated; n = 10 each) were fed a hypercholesterolemic diet for 48 days. Treated group then received supplemental CGJ (225 mL/day) while Control group received supplemental iso-caloric sugar water for 48 days. Collagen-, collagen + epinephrine- and phorbol-12-myristate-13-acetate-induced whole blood PA responses were measured on Days 0, 48 and 96; total serum cholesterol and blood pressure were also measured. The development of aortic atheroma was quantified at the end. Both groups showed significant increases in PA and serum cholesterol at Day 48. However, at Day 96, Treated group showed significantly lower PA and development of atheroma (30.7 ± 3.9% lower ( p < 0.001)) than Control group; Treated group also had significantly lower total serum cholesterol and blood pressure than Control group. In conclusion, daily consumption of CGJ attenuates hypercholesterolemia-enhanced PA, blood pressure, total serum cholesterol and development of atheroma in rabbits.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>16780846</pmid><doi>10.1016/j.atherosclerosis.2006.03.017</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Aorta - pathology Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - drug therapy Atherosclerosis - pathology Atherosclerosis - prevention & control Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Blood Pressure - drug effects Blood vessels and receptors Body Weight - drug effects Cardiology. Vascular system Cardiovascular Cholesterol Cholesterol - blood Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Grape juice Hypercholesterolemia Hypercholesterolemia - drug therapy Hypercholesterolemia - pathology Male Medical sciences Molecular and cellular biology Phenols - pharmacology Phytotherapy Platelet Platelet Aggregation - drug effects Platelets Polyphenolics Polyphenols Rabbits Vertebrates: cardiovascular system Vitis |
| title | Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits |
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