Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat : contribution of hyperglycaemia and matrix metalloproteinases

Although diabetes mellitus is associated with peripheral microvascular complications and increased risk of neurological events, the mechanisms by which diabetes disrupts the blood-brain barrier (BBB) are not known. Matrix metalloproteinase (MMP) activity is increased in diabetic patients, is associa...

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Veröffentlicht in:	Diabetologia 2007-01, Vol.50 (1), p.202-211
Hauptverfasser:	HAWKINS, B. T, LUNDEEN, T. F, NORWOOD, K. M, BROOKS, H. L, EGLETON, R. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood-Brain Barrier - physiopathology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Claudin-5 Diabetes Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Glucose Hyperglycemia Hyperglycemia - physiopathology Hypotheses Insulin Laboratory animals Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Medical sciences Membrane Proteins - metabolism Occludin Permeability Phosphoproteins - metabolism Plasma Proteins Rats Rats, Sprague-Dawley Streptozocin Sucrose Tight Junctions - physiology Vertebrates: nervous system and sense organs Zonula Occludens-1 Protein
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