Topical Delivery of Silver Nanoparticles Promotes Wound Healing
Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing...
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| Veröffentlicht in: | ChemMedChem 2007-01, Vol.2 (1), p.129-136 |
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| creator | Tian, Jun Wong, Kenneth K. Y. Ho, Chi-Ming Lok, Chun-Nam Yu, Wing-Yiu Che, Chi-Ming Chiu, Jen-Fu Tam, Paul K. H. |
| description | Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound‐healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose‐dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.
A healing touch: The ability to produce silver nanoparticles has enabled us to elucidate the effects of silver on wound healing. We demonstrate that silver nanoparticles significantly decrease the time of burn wound healing in an animal model. The results provide a novel therapeutic direction for wound treatment in clinical practice. |
| doi_str_mv | 10.1002/cmdc.200600171 |
| format | Article |
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A healing touch: The ability to produce silver nanoparticles has enabled us to elucidate the effects of silver on wound healing. We demonstrate that silver nanoparticles significantly decrease the time of burn wound healing in an animal model. 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| subjects | Administration, Topical Animals Anti-Bacterial Agents - administration & dosage cytokines Cytokines - metabolism medicinal chemistry Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Mice nanostructures proteomics silver Silver - administration & dosage Time Factors wound healing Wound Healing - drug effects Wound Infection - pathology Wound Infection - prevention & control |
| title | Topical Delivery of Silver Nanoparticles Promotes Wound Healing |
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