Up-Regulation of Thrombin Activity Induced by Vascular Endothelial Growth Factor in Asthmatic Airways

High expression of vascular endothelial growth factor (VEGF) induces subepithelial fibrosis associated with angiogenesis in patients with asthma. Thrombin is recognized as a new candidate mediating airway remodeling. Therefore, this study was designed to determine the role of up-regulated thrombin a...

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Veröffentlicht in:	Chest 2007-10, Vol.132 (4), p.1169-1174
Hauptverfasser:	Kanazawa, Hiroshi, Yoshikawa, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult airway remodeling Asthma - physiopathology basic fibroblast growth factor Biological and medical sciences Cardiology. Vascular system Chronic obstructive pulmonary disease, asthma Female Fibroblast Growth Factor 2 - blood Humans induced sputum Male Medical sciences Pneumology Protein C - metabolism Sputum - chemistry Thrombin - physiology Up-Regulation - physiology Vascular Endothelial Growth Factor A - physiology
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