Differences in Cardiopulmonary Exercise Test Results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease Stage Categories and Gender
The American Thoracic Society (ATS)/European Respiratory Society (ERS)-Global Initiative for Chronic Obstructive Lung Disease (GOLD) has developed a new staging system based on the degree of airflow obstruction. Its validity to predict exercise capacity as an outcome has not been extensively studied...
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| Veröffentlicht in: | Chest 2007-10, Vol.132 (4), p.1204-1211 |
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| creator | Pinto-Plata, Victor M. Celli-Cruz, Romulo A. Vassaux, Carlos Torre-Bouscoulet, Luis Mendes, Asante Rassulo, John Celli, Bartolome R. |
| description | The American Thoracic Society (ATS)/European Respiratory Society (ERS)-Global Initiative for Chronic Obstructive Lung Disease (GOLD) has developed a new staging system based on the degree of airflow obstruction. Its validity to predict exercise capacity as an outcome has not been extensively studied. We hypothesized that exercise performance measured by cardiopulmonary exercise test (CPET) results should decline significantly with each disease stage, independent of gender.
We examined 453 consecutive incremental CPET and pulmonary function tests performed in patients who had been referred to a single respiratory physiology laboratory in a tertiary care hospital. They were divided into a control group (normal lung function) and ATS/ERS-GOLD stages 1 to 4. We measured anthropometrics, peak work (in watts), peak oxygen uptake (in liters per kilogram per minute and percent predicted), breathing reserve (in percent predicted), and arterial blood gas response. We compared these results between different stages and genders.
The mean (± SD) age for the entire group was 64 ± 11 years, the mean FEV1 was 66 ± 28%, and the mean body mass index (BMI) was 27.2 ± 5.82 kg/m2. Patients in stage 4 were significantly younger (p < 0.001) and had a lower BMI (p < 0.02) compared to those in stages 1 to 3. There was a significant reduction in exercise capacity for patients at every stage except for those in stage 1, who had values similar to those of the control group. Women had better lung function and exercise capacity than men, but the difference disappeared when adjusted by COPD stages.
The ATS/ERS-GOLD staging system can be used to indicate differences in exercise capacity in patients with COPD stages 2 to 4 and to normalize apparent gender disparities. The value of differentiating stage 1 patients requires further studies with different outcomes. |
| doi_str_mv | 10.1378/chest.07-0593 |
| format | Article |
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We examined 453 consecutive incremental CPET and pulmonary function tests performed in patients who had been referred to a single respiratory physiology laboratory in a tertiary care hospital. They were divided into a control group (normal lung function) and ATS/ERS-GOLD stages 1 to 4. We measured anthropometrics, peak work (in watts), peak oxygen uptake (in liters per kilogram per minute and percent predicted), breathing reserve (in percent predicted), and arterial blood gas response. We compared these results between different stages and genders.
The mean (± SD) age for the entire group was 64 ± 11 years, the mean FEV1 was 66 ± 28%, and the mean body mass index (BMI) was 27.2 ± 5.82 kg/m2. Patients in stage 4 were significantly younger (p < 0.001) and had a lower BMI (p < 0.02) compared to those in stages 1 to 3. There was a significant reduction in exercise capacity for patients at every stage except for those in stage 1, who had values similar to those of the control group. Women had better lung function and exercise capacity than men, but the difference disappeared when adjusted by COPD stages.
The ATS/ERS-GOLD staging system can be used to indicate differences in exercise capacity in patients with COPD stages 2 to 4 and to normalize apparent gender disparities. The value of differentiating stage 1 patients requires further studies with different outcomes.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.07-0593</identifier><identifier>PMID: 17934113</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Aged ; arterial blood gas ; Biological and medical sciences ; Blood Gas Analysis ; Cardiology. Vascular system ; Chronic obstructive pulmonary disease, asthma ; COPD ; dyspnea ; Exercise Test ; Exercise Tolerance - physiology ; Female ; Humans ; Lung Diseases, Obstructive - diagnosis ; Lung Diseases, Obstructive - epidemiology ; Lung Diseases, Obstructive - physiopathology ; Male ; Medical sciences ; Middle Aged ; Oxygen Consumption ; Pneumology ; Pulmonary Gas Exchange ; Respiratory Function Tests ; Respiratory system : syndromes and miscellaneous diseases ; Risk Factors ; Smoking - epidemiology</subject><ispartof>Chest, 2007-10, Vol.132 (4), p.1204-1211</ispartof><rights>2007 The American College of Chest Physicians</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-358959091256767e192a27e3d010219bf49af4ba1fc7bdb19136a10ee389a01c3</citedby><cites>FETCH-LOGICAL-c391t-358959091256767e192a27e3d010219bf49af4ba1fc7bdb19136a10ee389a01c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19189610$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17934113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinto-Plata, Victor M.</creatorcontrib><creatorcontrib>Celli-Cruz, Romulo A.</creatorcontrib><creatorcontrib>Vassaux, Carlos</creatorcontrib><creatorcontrib>Torre-Bouscoulet, Luis</creatorcontrib><creatorcontrib>Mendes, Asante</creatorcontrib><creatorcontrib>Rassulo, John</creatorcontrib><creatorcontrib>Celli, Bartolome R.</creatorcontrib><title>Differences in Cardiopulmonary Exercise Test Results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease Stage Categories and Gender</title><title>Chest</title><addtitle>Chest</addtitle><description>The American Thoracic Society (ATS)/European Respiratory Society (ERS)-Global Initiative for Chronic Obstructive Lung Disease (GOLD) has developed a new staging system based on the degree of airflow obstruction. Its validity to predict exercise capacity as an outcome has not been extensively studied. We hypothesized that exercise performance measured by cardiopulmonary exercise test (CPET) results should decline significantly with each disease stage, independent of gender.
We examined 453 consecutive incremental CPET and pulmonary function tests performed in patients who had been referred to a single respiratory physiology laboratory in a tertiary care hospital. They were divided into a control group (normal lung function) and ATS/ERS-GOLD stages 1 to 4. We measured anthropometrics, peak work (in watts), peak oxygen uptake (in liters per kilogram per minute and percent predicted), breathing reserve (in percent predicted), and arterial blood gas response. We compared these results between different stages and genders.
The mean (± SD) age for the entire group was 64 ± 11 years, the mean FEV1 was 66 ± 28%, and the mean body mass index (BMI) was 27.2 ± 5.82 kg/m2. Patients in stage 4 were significantly younger (p < 0.001) and had a lower BMI (p < 0.02) compared to those in stages 1 to 3. There was a significant reduction in exercise capacity for patients at every stage except for those in stage 1, who had values similar to those of the control group. Women had better lung function and exercise capacity than men, but the difference disappeared when adjusted by COPD stages.
The ATS/ERS-GOLD staging system can be used to indicate differences in exercise capacity in patients with COPD stages 2 to 4 and to normalize apparent gender disparities. The value of differentiating stage 1 patients requires further studies with different outcomes.</description><subject>Aged</subject><subject>arterial blood gas</subject><subject>Biological and medical sciences</subject><subject>Blood Gas Analysis</subject><subject>Cardiology. Vascular system</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>COPD</subject><subject>dyspnea</subject><subject>Exercise Test</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Diseases, Obstructive - diagnosis</subject><subject>Lung Diseases, Obstructive - epidemiology</subject><subject>Lung Diseases, Obstructive - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxygen Consumption</subject><subject>Pneumology</subject><subject>Pulmonary Gas Exchange</subject><subject>Respiratory Function Tests</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Risk Factors</subject><subject>Smoking - epidemiology</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kjFv2zAQhYWiReOmHbsWXNpNCU-UJXEMHNcNYCBA484ERZ1sBhTpklJS_7z-s55jA5k6EeR9997hHrPsM_ArEHVzbXaYxite53wuxZtsBlJALualeJvNOIciF5UsLrIPKT1yuoOs3mcXUEtRAohZ9vfW9j1G9AYTs54tdOxs2E9uCF7HA1v-wWhsQrYhG_YT0-TGxNoDuxkwWqM92-xC1MYa9hCMxfFwvZxi2CNViN7bqMdAOudivnKh1Y7deTtaPdonZH2IbLGLwZPEfZvGOJmX9_Xkt-yWrDW5P4x6izTciNsQLY2qfcdW6DuMH7N3vXYJP53Py-zX9-Vm8SNf36_uFjfr3AgJI62kkXPJJRTzqq5qBFnookbRceAFyLYvpe7LVkNv6rZrQYKoNHBE0UjNwYjL7NtJdx_D74m2oQabDDqnPYYpqaoRDRd1SWB-Ak0MKUXs1T7agZapgKtjZuolM8VrdcyM-C9n4akdsHulzyER8PUM6GS066P2FMkrJ6GRFXDi-Inb2e3u2UZUadDOkaw4WT6GKXrtQBSqVFDw46z1qQVpc08Wo0qUE32GjtrNqLpg_zP1PxWCyCk</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Pinto-Plata, Victor M.</creator><creator>Celli-Cruz, Romulo A.</creator><creator>Vassaux, Carlos</creator><creator>Torre-Bouscoulet, Luis</creator><creator>Mendes, Asante</creator><creator>Rassulo, John</creator><creator>Celli, Bartolome R.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Differences in Cardiopulmonary Exercise Test Results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease Stage Categories and Gender</title><author>Pinto-Plata, Victor M. ; Celli-Cruz, Romulo A. ; Vassaux, Carlos ; Torre-Bouscoulet, Luis ; Mendes, Asante ; Rassulo, John ; Celli, Bartolome R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-358959091256767e192a27e3d010219bf49af4ba1fc7bdb19136a10ee389a01c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>arterial blood gas</topic><topic>Biological and medical sciences</topic><topic>Blood Gas Analysis</topic><topic>Cardiology. Vascular system</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>COPD</topic><topic>dyspnea</topic><topic>Exercise Test</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Diseases, Obstructive - diagnosis</topic><topic>Lung Diseases, Obstructive - epidemiology</topic><topic>Lung Diseases, Obstructive - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oxygen Consumption</topic><topic>Pneumology</topic><topic>Pulmonary Gas Exchange</topic><topic>Respiratory Function Tests</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Risk Factors</topic><topic>Smoking - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinto-Plata, Victor M.</creatorcontrib><creatorcontrib>Celli-Cruz, Romulo A.</creatorcontrib><creatorcontrib>Vassaux, Carlos</creatorcontrib><creatorcontrib>Torre-Bouscoulet, Luis</creatorcontrib><creatorcontrib>Mendes, Asante</creatorcontrib><creatorcontrib>Rassulo, John</creatorcontrib><creatorcontrib>Celli, Bartolome R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinto-Plata, Victor M.</au><au>Celli-Cruz, Romulo A.</au><au>Vassaux, Carlos</au><au>Torre-Bouscoulet, Luis</au><au>Mendes, Asante</au><au>Rassulo, John</au><au>Celli, Bartolome R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in Cardiopulmonary Exercise Test Results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease Stage Categories and Gender</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2007-10</date><risdate>2007</risdate><volume>132</volume><issue>4</issue><spage>1204</spage><epage>1211</epage><pages>1204-1211</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>The American Thoracic Society (ATS)/European Respiratory Society (ERS)-Global Initiative for Chronic Obstructive Lung Disease (GOLD) has developed a new staging system based on the degree of airflow obstruction. Its validity to predict exercise capacity as an outcome has not been extensively studied. We hypothesized that exercise performance measured by cardiopulmonary exercise test (CPET) results should decline significantly with each disease stage, independent of gender.
We examined 453 consecutive incremental CPET and pulmonary function tests performed in patients who had been referred to a single respiratory physiology laboratory in a tertiary care hospital. They were divided into a control group (normal lung function) and ATS/ERS-GOLD stages 1 to 4. We measured anthropometrics, peak work (in watts), peak oxygen uptake (in liters per kilogram per minute and percent predicted), breathing reserve (in percent predicted), and arterial blood gas response. We compared these results between different stages and genders.
The mean (± SD) age for the entire group was 64 ± 11 years, the mean FEV1 was 66 ± 28%, and the mean body mass index (BMI) was 27.2 ± 5.82 kg/m2. Patients in stage 4 were significantly younger (p < 0.001) and had a lower BMI (p < 0.02) compared to those in stages 1 to 3. There was a significant reduction in exercise capacity for patients at every stage except for those in stage 1, who had values similar to those of the control group. Women had better lung function and exercise capacity than men, but the difference disappeared when adjusted by COPD stages.
The ATS/ERS-GOLD staging system can be used to indicate differences in exercise capacity in patients with COPD stages 2 to 4 and to normalize apparent gender disparities. The value of differentiating stage 1 patients requires further studies with different outcomes.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>17934113</pmid><doi>10.1378/chest.07-0593</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged arterial blood gas Biological and medical sciences Blood Gas Analysis Cardiology. Vascular system Chronic obstructive pulmonary disease, asthma COPD dyspnea Exercise Test Exercise Tolerance - physiology Female Humans Lung Diseases, Obstructive - diagnosis Lung Diseases, Obstructive - epidemiology Lung Diseases, Obstructive - physiopathology Male Medical sciences Middle Aged Oxygen Consumption Pneumology Pulmonary Gas Exchange Respiratory Function Tests Respiratory system : syndromes and miscellaneous diseases Risk Factors Smoking - epidemiology |
| title | Differences in Cardiopulmonary Exercise Test Results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease Stage Categories and Gender |
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