Non-invasive imaging of neuropathology in a rat model of α-synuclein overexpression

Abstract Parkinson's disease is a neurodegenerative disorder affecting the dopaminergic neurons in the substantia nigra. Aggregation of α-synuclein appears to play a central role in the pathogenesis. Novel animal models for neurodegeneration have been generated by lentiviral vector-mediated loc...

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Veröffentlicht in:	Neurobiology of aging 2007-02, Vol.28 (2), p.248-257
Hauptverfasser:	Lauwers, Erwin, Bequé, Dirk, Van Laere, Koen, Nuyts, Johan, Bormans, Guy, Mortelmans, Luc, Casteels, Cindy, Vercammen, Linda, Bockstael, Olivier, Nuttin, Bart, Debyser, Zeger, Baekelandt, Veerle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies alpha-Synuclein - genetics alpha-Synuclein - metabolism Animal model Animals Behavior, Animal Biological and medical sciences Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Dopamine Plasma Membrane Transport Proteins - metabolism Follow-Up Studies Internal Medicine Medical sciences Neurodegeneration Neurology Organic mental disorders. Neuropsychology Parkinson Disease - diagnostic imaging Parkinson Disease - physiopathology Parkinson's disease Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radionuclide Imaging Rats Rats, Wistar SPECT α-Synuclein
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