PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells

Pigment epithelial-derived factor (PEDF) is a potent anti-angiogenic factor whose effects are partially mediated through the induction of endothelial cell apoptosis. The pathway mediating endothelial cell apoptosis has not been fully established. Here we investigated the participation of peroxisome...

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Veröffentlicht in:	Cardiovascular research 2007-11, Vol.76 (2), p.213-223
Hauptverfasser:	HO, T.-C, CHEN, S.-L, YANG, Y.-C, LIAO, C.-L, CHENG, H.-C, TSAO, Y.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Cardiology. Vascular system Caspases - physiology Cells, Cultured Endothelial Cells - physiology Eye Proteins - physiology Humans Medical sciences Nerve Growth Factors - physiology PPAR gamma - physiology Serpins - physiology Signal Transduction - physiology Transcription, Genetic Tumor Suppressor Protein p53 - physiology Umbilical Veins - cytology
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