Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation

Abstract Cardiac hypertrophy is an independent predictor of cardiovascular morbidity and mortality. It predisposes patients to heart failure, QT interval prolongation and ventricular arrhythmias. Angiotensin II (Ang II) exerts direct actions on cardiac tissue inducing cardiomyocyte hypertrophy and e...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2007-01, Vol.42 (1), p.63-70
Hauptverfasser:	Domenighetti, Andrea A, Boixel, Christophe, Cefai, Daniel, Abriel, Hugues, Pedrazzini, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials Angiotensin II Angiotensin II - genetics Angiotensin II - physiology Animals Arrhythmia Base Sequence Cardiac hypertrophy Cardiomegaly - etiology Cardiomegaly - genetics Cardiomegaly - physiopathology Cardiovascular Disease Models, Animal DNA Primers - genetics Down-Regulation Electrocardiography Heart failure Humans IK1 In Vitro Techniques Intermediate-Conductance Calcium-Activated Potassium Channels - genetics Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism Long QT syndrome Long QT Syndrome - etiology Long QT Syndrome - genetics Long QT Syndrome - physiopathology Male Mice Mice, Transgenic Myocytes, Cardiac - physiology Patch-Clamp Techniques Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Renin–angiotensin system RNA, Messenger - genetics RNA, Messenger - metabolism
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