Intrahepatic delivery of α‐galactosylceramide‐pulsed dendritic cells suppresses liver tumor

Alpha‐galactosylceramide, a glycosphingolipid, mediates interaction of dendritic cells (DCs) and NKT cells, leading to activation of both innate and acquired immunity. For cancer treatment, conventional DC‐based vaccine has been tried, but its clinical efficacy is limited against liver cancer. Intra...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2007-01, Vol.45 (1), p.22-30
Hauptverfasser:	Tatsumi, Tomohide, Takehara, Tetsuo, Yamaguchi, Shinjiro, Sasakawa, Akira, Sakamori, Ryotaro, Ohkawa, Kazuyoshi, Kohga, Keisuke, Uemura, Akio, Hayashi, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Communication - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell- and Tissue-Based Therapy - methods Dendritic Cells - cytology Dendritic Cells - drug effects Female Galactosylceramides - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Immunity, Innate Immunotherapy - methods Injections Interferon-gamma - blood Killer Cells, Natural - pathology Killer Cells, Natural - physiology Liver Neoplasms - pathology Liver Neoplasms - therapy Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, Inbred BALB C Tumor Suppressor Protein p53 - pharmacology Tumors
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