Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders
The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6-sulphatoxymelatonin (aMT6S) in urine, is a defining feature of suprachiasmatic nucleus (SCN) function, the endogenous oscillatory pacemaker. A substantial number of studies have shown that, within this rhythmic p...
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| creator | Pandi-Perumal, Seithikurippu R. Smits, Marcel Spence, Warren Srinivasan, Venkataramanujan Cardinali, Daniel P. Lowe, Alan D. Kayumov, Leonid |
| description | The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6-sulphatoxymelatonin (aMT6S) in urine, is a defining feature of suprachiasmatic nucleus (SCN) function, the endogenous oscillatory pacemaker. A substantial number of studies have shown that, within this rhythmic profile, the onset of melatonin secretion under dim light conditions (the dim light melatonin onset or DLMO) is the single most accurate marker for assessing the circadian pacemaker. Additionally, melatonin onset has been used clinically to evaluate problems related to the onset or offset of sleep. DLMO is useful for determining whether an individual is entrained (synchronized) to a 24-h light/dark (LD) cycle or is in a free-running state. DLMO is also useful for assessing phase delays or advances of rhythms in entrained individuals. Additionally, it has become an important tool for psychiatric diagnosis, its use being recommended for phase typing in patients suffering from sleep and mood disorders. More recently, DLMO has also been used to assess the chronobiological features of seasonal affective disorder (SAD). DLMO marker is also useful for identifying optimal application times for therapies such as bright light or exogenous melatonin treatment. |
| doi_str_mv | 10.1016/j.pnpbp.2006.06.020 |
| format | Article |
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A substantial number of studies have shown that, within this rhythmic profile, the onset of melatonin secretion under dim light conditions (the dim light melatonin onset or DLMO) is the single most accurate marker for assessing the circadian pacemaker. Additionally, melatonin onset has been used clinically to evaluate problems related to the onset or offset of sleep. DLMO is useful for determining whether an individual is entrained (synchronized) to a 24-h light/dark (LD) cycle or is in a free-running state. DLMO is also useful for assessing phase delays or advances of rhythms in entrained individuals. Additionally, it has become an important tool for psychiatric diagnosis, its use being recommended for phase typing in patients suffering from sleep and mood disorders. More recently, DLMO has also been used to assess the chronobiological features of seasonal affective disorder (SAD). DLMO marker is also useful for identifying optimal application times for therapies such as bright light or exogenous melatonin treatment.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2006.06.020</identifier><identifier>PMID: 16884842</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Animals ; Biological and medical sciences ; Circadian Rhythm - physiology ; Circadian rhythms ; Delayed sleep phase syndrome ; Depression ; Dim light melatonin onset ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Humans ; Jet Lag Syndrome - physiopathology ; Light ; Light/dark cycle ; Medical sciences ; Melatonin ; Melatonin - biosynthesis ; Mood disorders ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Periodicity ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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A substantial number of studies have shown that, within this rhythmic profile, the onset of melatonin secretion under dim light conditions (the dim light melatonin onset or DLMO) is the single most accurate marker for assessing the circadian pacemaker. Additionally, melatonin onset has been used clinically to evaluate problems related to the onset or offset of sleep. DLMO is useful for determining whether an individual is entrained (synchronized) to a 24-h light/dark (LD) cycle or is in a free-running state. DLMO is also useful for assessing phase delays or advances of rhythms in entrained individuals. Additionally, it has become an important tool for psychiatric diagnosis, its use being recommended for phase typing in patients suffering from sleep and mood disorders. More recently, DLMO has also been used to assess the chronobiological features of seasonal affective disorder (SAD). DLMO marker is also useful for identifying optimal application times for therapies such as bright light or exogenous melatonin treatment.</description><subject>Adult and adolescent clinical studies</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian rhythms</subject><subject>Delayed sleep phase syndrome</subject><subject>Depression</subject><subject>Dim light melatonin onset</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Humans</subject><subject>Jet Lag Syndrome - physiopathology</subject><subject>Light</subject><subject>Light/dark cycle</subject><subject>Medical sciences</subject><subject>Melatonin</subject><subject>Melatonin - biosynthesis</subject><subject>Mood disorders</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Periodicity</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Seasonal affective disorder</subject><subject>Sleep - physiology</subject><subject>Suprachiasmatic Nucleus - physiology</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVIady0vyAQdElpD3aklVaSCz2EpF_gkEt7FrOSNiujlTbSupD--sq1IbfCwMzA8w7Dg9AFJStKqLjerqY4ddOqIUSs9tWQE7SgSqolb6g4RQvS1LlVXJyhN6VsCSGUEfYanVGhFFe8WaA_d37EwT8OMx5dgDlFH3GKxc34w93m_uHjJ3yD55QC7lPG8-AwRAjPxRecemx8NmA9RDwNUByu2WE31rUE56aKWmyGnGLqfArp0RsI2PqSsnW5vEWvegjFvTv2c_Tr65eft9-Xm4dvP25vNkvDWzYvOQjeyPoxrFlPoVkby6EDwbhUYBRIZmS3XlvZq1a1nZGi66iQRLRMgG0lO0fvD3ennJ52rsx69MW4ECC6tCtaKCYladsKsgNociolu15P2Y-QnzUleq9cb_U_5XqvXO-rITV1eTy_60ZnXzJHxxW4OgJQqoA-QzS-vHCVIVzwyn0-cK7K-O1d1sV4F42zPjsza5v8fx_5CypboH8</recordid><startdate>20070130</startdate><enddate>20070130</enddate><creator>Pandi-Perumal, Seithikurippu R.</creator><creator>Smits, Marcel</creator><creator>Spence, Warren</creator><creator>Srinivasan, Venkataramanujan</creator><creator>Cardinali, Daniel P.</creator><creator>Lowe, Alan D.</creator><creator>Kayumov, Leonid</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070130</creationdate><title>Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders</title><author>Pandi-Perumal, Seithikurippu R. ; Smits, Marcel ; Spence, Warren ; Srinivasan, Venkataramanujan ; Cardinali, Daniel P. ; Lowe, Alan D. ; Kayumov, Leonid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-4a6427168a93f1a29cd4aba63478ac8a73c7b99d7f8585bc76bb16706536ad573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm - physiology</topic><topic>Circadian rhythms</topic><topic>Delayed sleep phase syndrome</topic><topic>Depression</topic><topic>Dim light melatonin onset</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Humans</topic><topic>Jet Lag Syndrome - physiopathology</topic><topic>Light</topic><topic>Light/dark cycle</topic><topic>Medical sciences</topic><topic>Melatonin</topic><topic>Melatonin - biosynthesis</topic><topic>Mood disorders</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Periodicity</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Seasonal affective disorder</topic><topic>Sleep - physiology</topic><topic>Suprachiasmatic Nucleus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandi-Perumal, Seithikurippu R.</creatorcontrib><creatorcontrib>Smits, Marcel</creatorcontrib><creatorcontrib>Spence, Warren</creatorcontrib><creatorcontrib>Srinivasan, Venkataramanujan</creatorcontrib><creatorcontrib>Cardinali, Daniel P.</creatorcontrib><creatorcontrib>Lowe, Alan D.</creatorcontrib><creatorcontrib>Kayumov, Leonid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandi-Perumal, Seithikurippu R.</au><au>Smits, Marcel</au><au>Spence, Warren</au><au>Srinivasan, Venkataramanujan</au><au>Cardinali, Daniel P.</au><au>Lowe, Alan D.</au><au>Kayumov, Leonid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2007-01-30</date><risdate>2007</risdate><volume>31</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6-sulphatoxymelatonin (aMT6S) in urine, is a defining feature of suprachiasmatic nucleus (SCN) function, the endogenous oscillatory pacemaker. 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| subjects | Adult and adolescent clinical studies Animals Biological and medical sciences Circadian Rhythm - physiology Circadian rhythms Delayed sleep phase syndrome Depression Dim light melatonin onset Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Humans Jet Lag Syndrome - physiopathology Light Light/dark cycle Medical sciences Melatonin Melatonin - biosynthesis Mood disorders Nervous system (semeiology, syndromes) Neurology Neuropharmacology Periodicity Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Seasonal affective disorder Sleep - physiology Suprachiasmatic Nucleus - physiology |
| title | Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders |
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