Long-lasting regeneration after ischemia in the cerebral cortex

Because fibroblast growth factor 2 is a mitogen for central nervous system stem cells, we explored whether long-term fibroblast growth factor 2 delivery to the brain can improve functional outcome and induce cortical neurogenesis after ischemia. Rats underwent permanent distal middle cerebral artery...

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Veröffentlicht in:	Stroke (1970) 2007, Vol.38 (1), p.153-161
Hauptverfasser:	LEKER, Ronen R, SOLDNER, Frank, VELASCO, Ivan, GAVIN, Denise K, ANDROUTSELLIS-THEOTOKIS, Andreas, MCKAY, Ronald D. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Animals Biological and medical sciences Biomarkers - metabolism Brain Infarction - genetics Brain Infarction - physiopathology Brain Infarction - therapy Brain Ischemia - genetics Brain Ischemia - physiopathology Brain Ischemia - therapy Bromodeoxyuridine Cell Proliferation Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Cerebral Cortex - virology Dependovirus - genetics Disease Models, Animal Fibroblast Growth Factor 2 - genetics Genetic Therapy - methods Genetic Vectors - genetics Green Fluorescent Proteins Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Medical sciences Nerve Regeneration - genetics Nerve Regeneration - physiology Nervous system (semeiology, syndromes) Neurology Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Rats Rats, Inbred SHR Recovery of Function - genetics Stem Cells - cytology Stem Cells - metabolism Transfection - methods Treatment Outcome Vascular diseases and vascular malformations of the nervous system
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