Long-lasting regeneration after ischemia in the cerebral cortex
Because fibroblast growth factor 2 is a mitogen for central nervous system stem cells, we explored whether long-term fibroblast growth factor 2 delivery to the brain can improve functional outcome and induce cortical neurogenesis after ischemia. Rats underwent permanent distal middle cerebral artery...
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| Veröffentlicht in: | Stroke (1970) 2007, Vol.38 (1), p.153-161 |
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| container_title | Stroke (1970) |
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| creator | LEKER, Ronen R SOLDNER, Frank VELASCO, Ivan GAVIN, Denise K ANDROUTSELLIS-THEOTOKIS, Andreas MCKAY, Ronald D. G |
| description | Because fibroblast growth factor 2 is a mitogen for central nervous system stem cells, we explored whether long-term fibroblast growth factor 2 delivery to the brain can improve functional outcome and induce cortical neurogenesis after ischemia.
Rats underwent permanent distal middle cerebral artery occlusion resulting in an ischemic injury limited to the cortex. We used an adeno-associated virus transfection system to induce long-term fibroblast growth factor 2 expression and monitored behavioral and histological changes.
Treatment increased the number of proliferating cells and improved motor behavior. Neurogenesis continued throughout 90 days after the ischemia, and the occurrence of newly generated cells with characteristics of neural precursors and immature neurons was most evident 90 days after treatment.
Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome. |
| doi_str_mv | 10.1161/01.str.0000252156.65953.a9 |
| format | Article |
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Rats underwent permanent distal middle cerebral artery occlusion resulting in an ischemic injury limited to the cortex. We used an adeno-associated virus transfection system to induce long-term fibroblast growth factor 2 expression and monitored behavioral and histological changes.
Treatment increased the number of proliferating cells and improved motor behavior. Neurogenesis continued throughout 90 days after the ischemia, and the occurrence of newly generated cells with characteristics of neural precursors and immature neurons was most evident 90 days after treatment.
Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.str.0000252156.65953.a9</identifier><identifier>PMID: 17122419</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adeno-associated virus ; Animals ; Biological and medical sciences ; Biomarkers - metabolism ; Brain Infarction - genetics ; Brain Infarction - physiopathology ; Brain Infarction - therapy ; Brain Ischemia - genetics ; Brain Ischemia - physiopathology ; Brain Ischemia - therapy ; Bromodeoxyuridine ; Cell Proliferation ; Cerebral Cortex - metabolism ; Cerebral Cortex - physiopathology ; Cerebral Cortex - virology ; Dependovirus - genetics ; Disease Models, Animal ; Fibroblast Growth Factor 2 - genetics ; Genetic Therapy - methods ; Genetic Vectors - genetics ; Green Fluorescent Proteins ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Infarction, Middle Cerebral Artery - drug therapy ; Infarction, Middle Cerebral Artery - pathology ; Infarction, Middle Cerebral Artery - physiopathology ; Medical sciences ; Nerve Regeneration - genetics ; Nerve Regeneration - physiology ; Nervous system (semeiology, syndromes) ; Neurology ; Neuronal Plasticity - genetics ; Neuronal Plasticity - physiology ; Neuropharmacology ; Neuroprotective agent ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred SHR ; Recovery of Function - genetics ; Stem Cells - cytology ; Stem Cells - metabolism ; Transfection - methods ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2007, Vol.38 (1), p.153-161</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-b18f08c2e8b112c5cff713cf5d31cd4f46de348079b2fd33a2c208cf142669743</citedby><cites>FETCH-LOGICAL-c553t-b18f08c2e8b112c5cff713cf5d31cd4f46de348079b2fd33a2c208cf142669743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18430066$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17122419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEKER, Ronen R</creatorcontrib><creatorcontrib>SOLDNER, Frank</creatorcontrib><creatorcontrib>VELASCO, Ivan</creatorcontrib><creatorcontrib>GAVIN, Denise K</creatorcontrib><creatorcontrib>ANDROUTSELLIS-THEOTOKIS, Andreas</creatorcontrib><creatorcontrib>MCKAY, Ronald D. G</creatorcontrib><title>Long-lasting regeneration after ischemia in the cerebral cortex</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Because fibroblast growth factor 2 is a mitogen for central nervous system stem cells, we explored whether long-term fibroblast growth factor 2 delivery to the brain can improve functional outcome and induce cortical neurogenesis after ischemia.
Rats underwent permanent distal middle cerebral artery occlusion resulting in an ischemic injury limited to the cortex. We used an adeno-associated virus transfection system to induce long-term fibroblast growth factor 2 expression and monitored behavioral and histological changes.
Treatment increased the number of proliferating cells and improved motor behavior. Neurogenesis continued throughout 90 days after the ischemia, and the occurrence of newly generated cells with characteristics of neural precursors and immature neurons was most evident 90 days after treatment.
Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome.</description><subject>Adeno-associated virus</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Brain Infarction - genetics</subject><subject>Brain Infarction - physiopathology</subject><subject>Brain Infarction - therapy</subject><subject>Brain Ischemia - genetics</subject><subject>Brain Ischemia - physiopathology</subject><subject>Brain Ischemia - therapy</subject><subject>Bromodeoxyuridine</subject><subject>Cell Proliferation</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cerebral Cortex - virology</subject><subject>Dependovirus - genetics</subject><subject>Disease Models, Animal</subject><subject>Fibroblast Growth Factor 2 - genetics</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors - genetics</subject><subject>Green Fluorescent Proteins</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Infarction, Middle Cerebral Artery - drug therapy</subject><subject>Infarction, Middle Cerebral Artery - pathology</subject><subject>Infarction, Middle Cerebral Artery - physiopathology</subject><subject>Medical sciences</subject><subject>Nerve Regeneration - genetics</subject><subject>Nerve Regeneration - physiology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuronal Plasticity - genetics</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Recovery of Function - genetics</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Transfection - methods</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLxDAQB_Agiq6PryBF0FtrJq8mXkQWX7Ag6HoOaTrZrXRbTbqg396qC3t0LnP5zYM_IWdACwAFlxSKNMSCjsUkA6kKJY3khTM7ZAKSiVwopnfJhFJuciaMOSCHKb39eK7lPjmAEhgTYCbketZ3i7x1aWi6RRZxgR1GNzR9l7kwYMya5Je4alzWdNmwxMxjxCq6NvN9HPDzmOwF1yY82fQj8np3O58-5LOn-8fpzSz3UvIhr0AHqj1DXQEwL30IJXAfZM3B1yIIVSMXmpamYqHm3DHPRh9AMKVMKfgRufjb-x77jzWmwa7Gz7BtXYf9OlmleamkYP9CMFpoAWqEV3_Qxz6liMG-x2bl4pcFan9ythTsy_zZbnO2vzlbZ8bh082VdbXCeju6CXYE5xvgkndtiK7zTdo6LTilSvFviS6GZQ</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>LEKER, Ronen R</creator><creator>SOLDNER, Frank</creator><creator>VELASCO, Ivan</creator><creator>GAVIN, Denise K</creator><creator>ANDROUTSELLIS-THEOTOKIS, Andreas</creator><creator>MCKAY, Ronald D. G</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>Long-lasting regeneration after ischemia in the cerebral cortex</title><author>LEKER, Ronen R ; SOLDNER, Frank ; VELASCO, Ivan ; GAVIN, Denise K ; ANDROUTSELLIS-THEOTOKIS, Andreas ; MCKAY, Ronald D. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-b18f08c2e8b112c5cff713cf5d31cd4f46de348079b2fd33a2c208cf142669743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adeno-associated virus</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Brain Infarction - genetics</topic><topic>Brain Infarction - physiopathology</topic><topic>Brain Infarction - therapy</topic><topic>Brain Ischemia - genetics</topic><topic>Brain Ischemia - physiopathology</topic><topic>Brain Ischemia - therapy</topic><topic>Bromodeoxyuridine</topic><topic>Cell Proliferation</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cerebral Cortex - virology</topic><topic>Dependovirus - genetics</topic><topic>Disease Models, Animal</topic><topic>Fibroblast Growth Factor 2 - genetics</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors - genetics</topic><topic>Green Fluorescent Proteins</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Infarction, Middle Cerebral Artery - drug therapy</topic><topic>Infarction, Middle Cerebral Artery - pathology</topic><topic>Infarction, Middle Cerebral Artery - physiopathology</topic><topic>Medical sciences</topic><topic>Nerve Regeneration - genetics</topic><topic>Nerve Regeneration - physiology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuronal Plasticity - genetics</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Recovery of Function - genetics</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Transfection - methods</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEKER, Ronen R</creatorcontrib><creatorcontrib>SOLDNER, Frank</creatorcontrib><creatorcontrib>VELASCO, Ivan</creatorcontrib><creatorcontrib>GAVIN, Denise K</creatorcontrib><creatorcontrib>ANDROUTSELLIS-THEOTOKIS, Andreas</creatorcontrib><creatorcontrib>MCKAY, Ronald D. 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G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-lasting regeneration after ischemia in the cerebral cortex</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2007</date><risdate>2007</risdate><volume>38</volume><issue>1</issue><spage>153</spage><epage>161</epage><pages>153-161</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Because fibroblast growth factor 2 is a mitogen for central nervous system stem cells, we explored whether long-term fibroblast growth factor 2 delivery to the brain can improve functional outcome and induce cortical neurogenesis after ischemia.
Rats underwent permanent distal middle cerebral artery occlusion resulting in an ischemic injury limited to the cortex. We used an adeno-associated virus transfection system to induce long-term fibroblast growth factor 2 expression and monitored behavioral and histological changes.
Treatment increased the number of proliferating cells and improved motor behavior. Neurogenesis continued throughout 90 days after the ischemia, and the occurrence of newly generated cells with characteristics of neural precursors and immature neurons was most evident 90 days after treatment.
Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>17122419</pmid><doi>10.1161/01.str.0000252156.65953.a9</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Stroke (1970), 2007, Vol.38 (1), p.153-161 |
| issn | 0039-2499 1524-4628 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adeno-associated virus Animals Biological and medical sciences Biomarkers - metabolism Brain Infarction - genetics Brain Infarction - physiopathology Brain Infarction - therapy Brain Ischemia - genetics Brain Ischemia - physiopathology Brain Ischemia - therapy Bromodeoxyuridine Cell Proliferation Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Cerebral Cortex - virology Dependovirus - genetics Disease Models, Animal Fibroblast Growth Factor 2 - genetics Genetic Therapy - methods Genetic Vectors - genetics Green Fluorescent Proteins Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Medical sciences Nerve Regeneration - genetics Nerve Regeneration - physiology Nervous system (semeiology, syndromes) Neurology Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Rats Rats, Inbred SHR Recovery of Function - genetics Stem Cells - cytology Stem Cells - metabolism Transfection - methods Treatment Outcome Vascular diseases and vascular malformations of the nervous system |
| title | Long-lasting regeneration after ischemia in the cerebral cortex |
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