Degradation of vitamin D3 in a stressed formulation : The identification of esters of vitamin D3 formed by a transesterification with triglycerides
Four unknown degradants in the LC-UV profile of a stressed experimental tablet formulation that contains vitamin D3 have been identified by a combination of Ag+-cationization electrospray ionization (ESI) LC/MS and atmospheric pressure chemical ionization (APCI) LC/MS/MS. The peaks elute in the meth...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2007-01, Vol.43 (1), p.142-150 |
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| creator | BALLARD, John M LIMIN ZHU NELSON, Eric D SEBURG, Randal A |
| description | Four unknown degradants in the LC-UV profile of a stressed experimental tablet formulation that contains vitamin D3 have been identified by a combination of Ag+-cationization electrospray ionization (ESI) LC/MS and atmospheric pressure chemical ionization (APCI) LC/MS/MS. The peaks elute in the method chromatography in two pairs of two peaks. The first pair of peaks has m/z 511 while the second pair has m/z 539. The major, first peak of each set of peaks corresponds to the octanoate and decanoate ester of vitamin D3, respectively. These are formed by a transesterification with the two major fatty acid components (octanoate and decanoate) of the triglycerides present in the formulation. The formation of two degradation products with each fatty acid is due to the presence of both vitamin D3 (major component) and the isomeric pre-vitamin D3 (minor component) in the stressed formulation. |
| doi_str_mv | 10.1016/j.jpba.2006.06.036 |
| format | Article |
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The peaks elute in the method chromatography in two pairs of two peaks. The first pair of peaks has m/z 511 while the second pair has m/z 539. The major, first peak of each set of peaks corresponds to the octanoate and decanoate ester of vitamin D3, respectively. These are formed by a transesterification with the two major fatty acid components (octanoate and decanoate) of the triglycerides present in the formulation. 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The peaks elute in the method chromatography in two pairs of two peaks. The first pair of peaks has m/z 511 while the second pair has m/z 539. The major, first peak of each set of peaks corresponds to the octanoate and decanoate ester of vitamin D3, respectively. These are formed by a transesterification with the two major fatty acid components (octanoate and decanoate) of the triglycerides present in the formulation. The formation of two degradation products with each fatty acid is due to the presence of both vitamin D3 (major component) and the isomeric pre-vitamin D3 (minor component) in the stressed formulation.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>Cholecalciferol - chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug Stability</subject><subject>Esters - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Hot Temperature</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tablets</subject><subject>Triglycerides - analysis</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctKAzEUhoMotl5ewIXMRndTc5sk405ab1Bw04W7kMmlTZnO1GSq9Dl8YTO2WBAOCeR8_0_O-QG4QnCEIGJ3y9FyXakRhpCN-iLsCAyR4CTHjL4fgyHkBOUcimIAzmJcQggLVNJTMECsTAYcD8H3xM6DMqrzbZO1Lvv0nVr5JpuQLJ0qi12wMVqTuTasNvWOu89mC5t5Y5vOO6__xDZ2NsR_Nr0w6attcuuCauIvddB9-W6RGn5eb3V6NzZegBOn6mgv9_c5mD09zsYv-fTt-XX8MM01pqzLBSoLqCGmxhZCCGRJVSpLNRWCG8wqxRF3JSm5YBAbVxROI20IhRgr4gw5B7c723VoPzbpV3Llo7Z1rRrbbqJkgnAGEU0g3oE6tDEG6-Q6-JUKW4mg7JOQS9knIfskZF-EJdH13n1TpfkPkv3qE3CzB1TUqnZpNdrHAydoiosW5Af7kJSf</recordid><startdate>20070104</startdate><enddate>20070104</enddate><creator>BALLARD, John M</creator><creator>LIMIN ZHU</creator><creator>NELSON, Eric D</creator><creator>SEBURG, Randal A</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070104</creationdate><title>Degradation of vitamin D3 in a stressed formulation : The identification of esters of vitamin D3 formed by a transesterification with triglycerides</title><author>BALLARD, John M ; LIMIN ZHU ; NELSON, Eric D ; SEBURG, Randal A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c246t-81950c024de58881e3b9ae4c4887d26ba717f93978602df55fc1cd34022a3fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>Cholecalciferol - chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drug Stability</topic><topic>Esters - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Hot Temperature</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tablets</topic><topic>Triglycerides - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BALLARD, John M</creatorcontrib><creatorcontrib>LIMIN ZHU</creatorcontrib><creatorcontrib>NELSON, Eric D</creatorcontrib><creatorcontrib>SEBURG, Randal A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BALLARD, John M</au><au>LIMIN ZHU</au><au>NELSON, Eric D</au><au>SEBURG, Randal A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Degradation of vitamin D3 in a stressed formulation : The identification of esters of vitamin D3 formed by a transesterification with triglycerides</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2007-01-04</date><risdate>2007</risdate><volume>43</volume><issue>1</issue><spage>142</spage><epage>150</epage><pages>142-150</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Four unknown degradants in the LC-UV profile of a stressed experimental tablet formulation that contains vitamin D3 have been identified by a combination of Ag+-cationization electrospray ionization (ESI) LC/MS and atmospheric pressure chemical ionization (APCI) LC/MS/MS. The peaks elute in the method chromatography in two pairs of two peaks. The first pair of peaks has m/z 511 while the second pair has m/z 539. The major, first peak of each set of peaks corresponds to the octanoate and decanoate ester of vitamin D3, respectively. These are formed by a transesterification with the two major fatty acid components (octanoate and decanoate) of the triglycerides present in the formulation. The formation of two degradation products with each fatty acid is due to the presence of both vitamin D3 (major component) and the isomeric pre-vitamin D3 (minor component) in the stressed formulation.</abstract><cop>Amsterdam</cop><pub>Elsevier Science</pub><pmid>16901672</pmid><doi>10.1016/j.jpba.2006.06.036</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2007-01, Vol.43 (1), p.142-150 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chemistry, Pharmaceutical Cholecalciferol - chemistry Chromatography, High Pressure Liquid Drug Stability Esters - analysis Fundamental and applied biological sciences. Psychology General pharmacology Hot Temperature Medical sciences Pharmacology. Drug treatments Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Ultraviolet Tablets Triglycerides - analysis |
| title | Degradation of vitamin D3 in a stressed formulation : The identification of esters of vitamin D3 formed by a transesterification with triglycerides |
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